biostudies-literatureUnknownLopez Montesinos ITo compare clinical characteristics, outcomes, and resource consumption of patients with COVID-19 and seasonal influenza requiring supplemental oxygen. Retrospective cohort study conducted at a tertiary-care hospital. Patients admitted due to seasonal influenza between 2017 and 2019, or with COVID-19 between March and May 2020 requiring supplemental oxygen were compared. Primary outcome: 30-day mortality. Secondary outcomes: 90-day mortality and hospitalization costs. Attempted sample size to detect an 11% difference in mortality was 187 patients per group. COVID-19 cases were younger (median years, 67 (IQR 54-78) vs 76 (IQR 64-83); p < 0.001) and more frequently overweight whereas influenza cases had more hypertension, immunosuppression, and chronic heart, respiratory and renal disease. CClinical infectious diseases : an official publication of the Infectious Diseases Society of Americaciac314https://www.ebi.ac.uk/biostudies/studies/S-EPMC9047197biostudies-literatureComparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption.PMC9047197Knobel HDuran XPelegrin IGomez-Junyent JBrase Arnau AArnau-Barres ISorli LCOVID-MAR GroupGomez-Zorrilla SGuerri-Fernandez RArrieta-Aldea ILopez Montesinos IDomingo Kamber IZuccarino FNogues XSiverio-Pares ACastaneda SSuaya Leiro LGrau SCanas-Ruano EVillar-Garcia JPablo Horcajada JDel Mar Arenas MDicastillo AMilagro Montero MSanchez Martinez FSendra EfalseComparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption.To compare clinical characteristics, outcomes, and resource consumption of patients with COVID-19 and seasonal influenza requiring supplemental oxygen. Retrospective cohort study conducted at a tertiary-care hospital. Patients admitted due to seasonal influenza between 2017 and 2019, or with COVID-19 between March and May 2020 requiring supplemental oxygen were compared. Primary outcome: 30-day mortality. Secondary outcomes: 90-day mortality and hospitalization costs. Attempted sample size to detect an 11% difference in mortality was 187 patients per group. COVID-19 cases were younger (median years, 67 (IQR 54-78) vs 76 (IQR 64-83); p < 0.001) and more frequently overweight whereas influenza cases had more hypertension, immunosuppression, and chronic heart, respiratory and renal disease. C2022-01-01T00:00:00Z2022 Apr2025-04-25T22:55:51.952Z2025-02-19T03:58:52.957ZS-EPMC90471973544244210.1093/cid/ciac314