{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Huazhong Agricultural University","Hubei Province"],"pagination":["1568-1576"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9047237"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["226(9)"],"pubmed_abstract":["Isolated reports of new-onset diabetes in patients with coronavirus disease 2019 (COVID-19) have led researchers to hypothesize that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects human exocrine and endocrine pancreatic cells ex vivo and in vivo. However, existing research lacks experimental evidence indicating that SARS-CoV-2 can infect pancreatic tissue. Here, we found that cats infected with a high dose of SARS-CoV-2 exhibited hyperglycemia. We also detected SARS-CoV-2 RNA in pancreatic tissues of these cats, and immunohistochemical staining revealed the presence of SARS-CoV-2 nucleocapsid protein (NP) in islet cells. SARS-CoV-2 NP and spike proteins were primarily detected in glucagon-positive cells, and most glucagon-positive cells expressed ACE2. Additionally, i"],"journal":["The Journal of infectious diseases"],"pubmed_title":["SARS-CoV-2 Infection Causes Hyperglycemia in Cats."],"pmcid":["PMC9047237"],"funding_grant_id":["2020FCA046","2662020PY002"],"pubmed_authors":["Zhao LZ","Wu C","Gao J","Huang K","Sun X","Zhao Y","Hu C","Zou Z","Yang Y","Zhang Y","Wang T","Jin M","Hui X","Chen X"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 Infection Causes Hyperglycemia in Cats.","description":"Isolated reports of new-onset diabetes in patients with coronavirus disease 2019 (COVID-19) have led researchers to hypothesize that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects human exocrine and endocrine pancreatic cells ex vivo and in vivo. However, existing research lacks experimental evidence indicating that SARS-CoV-2 can infect pancreatic tissue. Here, we found that cats infected with a high dose of SARS-CoV-2 exhibited hyperglycemia. We also detected SARS-CoV-2 RNA in pancreatic tissues of these cats, and immunohistochemical staining revealed the presence of SARS-CoV-2 nucleocapsid protein (NP) in islet cells. SARS-CoV-2 NP and spike proteins were primarily detected in glucagon-positive cells, and most glucagon-positive cells expressed ACE2. Additionally, i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T09:10:08.448Z","creation":"2025-02-19T03:58:52.494Z"},"accession":"S-EPMC9047237","cross_references":{"pubmed":["35639863"],"doi":["10.1093/infdis/jiac143"]}}