{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu AY"],"funding":["Anhui Medical University Research Foundation","Anhui Medical University Clinical Medicine Discipline Construction Project Clinical and Preliminary Co-construction Discipline Project","Anhui Key Research and Development Program","Clinical Medicine Discipline Construction Project of Anhui Medical University"],"pagination":["398"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9047266"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Background
The study aimed to investigate the effect of low-frequency electrical stimulation (LFES) on disuse muscle atrophy and its mechanism in a rabbit model of knee extension contracture.Methods
This study involved two experiments. In the time-point experiment, 24 rabbits were randomly divided into 4 groups: Control 1 (Ctrl1 group), immobilization for 2 weeks (I-2 group), immobilization for 4 weeks (I-4 group), and immobilization for 6 weeks (I-6 group). In the intervention experiment, 24 rabbits were randomly divided into 4 groups: Control 2 (Ctrl2 group), electrical stimulation (ESG group), natural recovery (NRG group), and electrical stimulation treatment (ESTG group). All intervention effects were assessed by evaluating the knee joint range of motion (ROM), cross-se"],"journal":["BMC musculoskeletal disorders"],"pubmed_title":["Low-frequency electrical stimulation alleviates immobilization-evoked disuse muscle atrophy by repressing autophagy in skeletal muscle of rabbits."],"pmcid":["PMC9047266"],"funding_grant_id":["amu202210","2018xkj050","2021LCXK031","201904a07020067"],"pubmed_authors":["Zhang QB","Zhong HZ","Huang PP","Xu QY","Wang F","Xiong YW","Wang H","Zhou Y","Liu AY","Zhu HL"],"additional_accession":[]},"is_claimable":false,"name":"Low-frequency electrical stimulation alleviates immobilization-evoked disuse muscle atrophy by repressing autophagy in skeletal muscle of rabbits.","description":"Background
The study aimed to investigate the effect of low-frequency electrical stimulation (LFES) on disuse muscle atrophy and its mechanism in a rabbit model of knee extension contracture.Methods
This study involved two experiments. In the time-point experiment, 24 rabbits were randomly divided into 4 groups: Control 1 (Ctrl1 group), immobilization for 2 weeks (I-2 group), immobilization for 4 weeks (I-4 group), and immobilization for 6 weeks (I-6 group). In the intervention experiment, 24 rabbits were randomly divided into 4 groups: Control 2 (Ctrl2 group), electrical stimulation (ESG group), natural recovery (NRG group), and electrical stimulation treatment (ESTG group). All intervention effects were assessed by evaluating the knee joint range of motion (ROM), cross-se","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-22T12:54:20.298Z","creation":"2025-04-06T00:28:14.066Z"},"accession":"S-EPMC9047266","cross_references":{"pubmed":["35484550"],"doi":["10.1186/s12891-022-05350-5"]}}