{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun YC"],"funding":["Chinese Academy of Fishery Sciences"],"pagination":["1552-1571"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9047290"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(3)"],"pubmed_abstract":["The aims of this study is to explore the metabolomic biomarker and pathway changes in crucian under carbonate alkalinity exposures using high-throughput metabolomics analysis based on ultra-performance liquid chromatography-electrospray ionization-quadrupole time of flight-tandem mass spectrometry (UPLC-ESI-QTOF-MS) for carrying out adaptive evolution of fish in environmental exposures and understanding molecular physiological mechanisms of saline-alkali tolerance in fishes. Under 60 day exposure management, the UPLC-ESI-QTOF-MS technology, coupled with a pattern recognition approach and metabolic pathway analysis, was utilized to give insight into the metabolic biomarker and pathway changes. In addition, biochemical parameters in response to carbonate alkalinity in fish were detected for "],"journal":["RSC advances"],"pubmed_title":["Exploring the metabolic biomarkers and pathway changes in crucian under carbonate alkalinity exposure using high-throughput metabolomics analysis based on UPLC-ESI-QTOF-MS."],"pmcid":["PMC9047290"],"funding_grant_id":["2016HY-ZD1205"],"pubmed_authors":["Wang YM","Sun YC","Han SC","Yao MZ","Liu HB"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the metabolic biomarkers and pathway changes in crucian under carbonate alkalinity exposure using high-throughput metabolomics analysis based on UPLC-ESI-QTOF-MS.","description":"The aims of this study is to explore the metabolomic biomarker and pathway changes in crucian under carbonate alkalinity exposures using high-throughput metabolomics analysis based on ultra-performance liquid chromatography-electrospray ionization-quadrupole time of flight-tandem mass spectrometry (UPLC-ESI-QTOF-MS) for carrying out adaptive evolution of fish in environmental exposures and understanding molecular physiological mechanisms of saline-alkali tolerance in fishes. Under 60 day exposure management, the UPLC-ESI-QTOF-MS technology, coupled with a pattern recognition approach and metabolic pathway analysis, was utilized to give insight into the metabolic biomarker and pathway changes. In addition, biochemical parameters in response to carbonate alkalinity in fish were detected for ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-04-05T14:43:20.329Z","creation":"2025-04-05T14:43:20.329Z"},"accession":"S-EPMC9047290","cross_references":{"pubmed":["35494719"],"doi":["10.1039/c9ra08090b"]}}