biostudies-literatureUnknown15(2)Weiss LParacelsus Medical UniversityThis short review reflects on a personal selection of three abstracts on colorectal cancer (CRC) presented at the 2021 ESMO Congress: (1) KRASG12C as a new therapeutic target in metastatic CRC, supported by data from the KRYSTAL‑1 and CodeBreaK101 trials, (2) positive phase 3 data on the possible role of selective internal radiotherapy (SIRT) in the second-line treatment of liver-limited metastatic CRC, and (3) the impact of the coronavirus disease 2019 (COVID-19) pandemic on CRC screening, management and mortality, now and in the upcoming years<i>.</i>Memo114-116https://www.ebi.ac.uk/biostudies/studies/S-EPMC9047589biostudies-literatureESMO 2021-highlights in colorectal cancer.PMC9047589Weiss LfalseESMO 2021-highlights in colorectal cancer.This short review reflects on a personal selection of three abstracts on colorectal cancer (CRC) presented at the 2021 ESMO Congress: (1) KRASG12C as a new therapeutic target in metastatic CRC, supported by data from the KRYSTAL‑1 and CodeBreaK101 trials, (2) positive phase 3 data on the possible role of selective internal radiotherapy (SIRT) in the second-line treatment of liver-limited metastatic CRC, and (3) the impact of the coronavirus disease 2019 (COVID-19) pandemic on CRC screening, management and mortality, now and in the upcoming years<i>.</i>2022-01-01T00:00:00Z20222025-04-18T12:13:29.32Z2025-04-06T21:52:15.246ZS-EPMC90475893550599910.1007/s12254-022-00808-7