biostudies-literatureAgrawal SNIA NIH HHSNINDS NIH HHSe229311https://www.ebi.ac.uk/biostudies/studies/S-EPMC9047640biostudies-literatureUnknown5(4)<h4>Importance</h4>A history of traumatic brain injury (TBI) has been considered a risk factor for Alzheimer dementia. However, the specific association of TBI, even without loss of consciousness (LOC), with pathologic findings that underlie Alzheimer dementia, including Alzheimer disease (AD), non-AD neurodegenerative, and vascular pathologic findings, remains unclear.<h4>Objective</h4>To examine the association between TBI with and without LOC and neuropathologic findings in community-based cohorts.<h4>Design, setting, and participants</h4>This cross-sectional analysis used neuropathologic data from 1689 participants from the Religious Orders Study, the Rush Memory and Aging Project, and the Minority Aging Research Study. These studies began enrollment in 1994, 1997, and 2004, respectiveJAMA network openAssociation of Traumatic Brain Injury With and Without Loss of Consciousness With Neuropathologic Outcomes in Community-Dwelling Older Persons.PMC9047640R01 AG015819P30 AG072975RF1 NS115268R01 AG022018R01 AG067482U54 NS115322P30 AG010161R01 AG061028R01 AG017917Agrawal SDams-O'Connor KMez JBarnes LLBennett DASchneider JAJames BDLeurgans SEMehta RIfalseAssociation of Traumatic Brain Injury With and Without Loss of Consciousness With Neuropathologic Outcomes in Community-Dwelling Older Persons.<h4>Importance</h4>A history of traumatic brain injury (TBI) has been considered a risk factor for Alzheimer dementia. However, the specific association of TBI, even without loss of consciousness (LOC), with pathologic findings that underlie Alzheimer dementia, including Alzheimer disease (AD), non-AD neurodegenerative, and vascular pathologic findings, remains unclear.<h4>Objective</h4>To examine the association between TBI with and without LOC and neuropathologic findings in community-based cohorts.<h4>Design, setting, and participants</h4>This cross-sectional analysis used neuropathologic data from 1689 participants from the Religious Orders Study, the Rush Memory and Aging Project, and the Minority Aging Research Study. These studies began enrollment in 1994, 1997, and 2004, respective2022-01-01T00:00:00Z2022 Apr2025-04-18T14:20:44.529Z2025-04-07T00:28:18.166ZS-EPMC90476403547606210.1001/jamanetworkopen.2022.9311