biostudies-literatureUnknown77(5)Miltgen GFrench Agricultural Research Centre for International DevelopmentIndian Ocean CommissionReunion Regional Health AgencyCIRADUMR PIMIT<h4>Background</h4>Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a major cause of infections worldwide. An understanding of the reservoirs and modes of transmission of these pathogens is essential, to tackle their increasing frequency.<h4>Objectives</h4>We investigated the contributions of various compartments (humans, animals, environment), to human colonization or infection with ESBL-Ec over a 3 year period, on an island.<h4>Methods</h4>The study was performed on Reunion Island (Southwest Indian Ocean). We collected ESBL-Ec isolates prospectively from humans, wastewater and livestock between April 2015 and December 2018. Human specimens were recovered from a regional surveillance system representative of the island's health facilities. These isolates were comparedThe Journal of antimicrobial chemotherapy1254-1262https://www.ebi.ac.uk/biostudies/studies/S-EPMC9047676biostudies-literatureOne Health compartmental analysis of ESBL-producing Escherichia coli on Reunion Island reveals partitioning between humans and livestock.PMC9047676Verchere GBelmonte OCardinale ERamiandrisoa MPicot SMasson GLignereux AMartak DBen Cimon CValot BMiltgen GJaffar-Bandjee MCHocquet DKamus LMavingui PGarrigos TBertrand XGbaguidi-Haore HfalseOne Health compartmental analysis of ESBL-producing Escherichia coli on Reunion Island reveals partitioning between humans and livestock.<h4>Background</h4>Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a major cause of infections worldwide. An understanding of the reservoirs and modes of transmission of these pathogens is essential, to tackle their increasing frequency.<h4>Objectives</h4>We investigated the contributions of various compartments (humans, animals, environment), to human colonization or infection with ESBL-Ec over a 3 year period, on an island.<h4>Methods</h4>The study was performed on Reunion Island (Southwest Indian Ocean). We collected ESBL-Ec isolates prospectively from humans, wastewater and livestock between April 2015 and December 2018. Human specimens were recovered from a regional surveillance system representative of the island's health facilities. These isolates were compared2022-01-01T00:00:00Z2022 Apr2026-05-31T06:04:30.136Z2025-02-19T01:55:28.433ZS-EPMC90476763519464710.1093/jac/dkac054