{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Sakowicz AM"],"pubmed_abstract":["We present the synthesis of new chiral water-soluble dimeric capsules by the multicomponent Mannich reaction between charged amino acids (glutamic acid or arginine), resorcinarene, and formaldehyde and by subsequent self-assembly. The zwitterionic character of the backbones enables electrostatic interactions between arms and induces self-assembly of dimeric capsules, namely, (L-<b>ArgR</b>)<sub>2</sub> and (L-<b>GluR</b>)<sub>2</sub>, in water with a wide range of pH, as demonstrated by NMR, diffusion coefficient measurement, and circular dichroism. The assembly/disassembly processes are fast on the NMR timescale. This mode of dimerization leaves side chains available for additional interactions and creates chiral cavities of mixed hydrophobic/hydrophilic character. According to this chara"],"journal":["Frontiers in chemistry"],"pagination":["883093"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9047736"],"repository":["biostudies-literature"],"pubmed_title":["Chiral Water-Soluble Molecular Capsules With Amphiphilic Interiors."],"pmcid":["PMC9047736"],"pubmed_authors":["Sakowicz AM","Szumna A"],"additional_accession":[]},"is_claimable":false,"name":"Chiral Water-Soluble Molecular Capsules With Amphiphilic Interiors.","description":"We present the synthesis of new chiral water-soluble dimeric capsules by the multicomponent Mannich reaction between charged amino acids (glutamic acid or arginine), resorcinarene, and formaldehyde and by subsequent self-assembly. The zwitterionic character of the backbones enables electrostatic interactions between arms and induces self-assembly of dimeric capsules, namely, (L-<b>ArgR</b>)<sub>2</sub> and (L-<b>GluR</b>)<sub>2</sub>, in water with a wide range of pH, as demonstrated by NMR, diffusion coefficient measurement, and circular dichroism. The assembly/disassembly processes are fast on the NMR timescale. This mode of dimerization leaves side chains available for additional interactions and creates chiral cavities of mixed hydrophobic/hydrophilic character. According to this chara","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-25T22:58:28.135Z","creation":"2025-04-06T09:12:52.667Z"},"accession":"S-EPMC9047736","cross_references":{"pubmed":["35494632"],"doi":["10.3389/fchem.2022.883093"]}}