{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kozlova EV"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["120153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9048156"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["288"],"pubmed_abstract":["<h4>Aims</h4>To characterize neuroinflammatory and gut dysbiosis signatures that accompany exaggerated exercise fatigue and cognitive/mood deficits in a mouse model of Gulf War Illness (GWI).<h4>Methods</h4>Adult male C57Bl/6N mice were exposed for 28 d (5 d/wk) to pyridostigmine bromide (P.O.) at 6.5 mg/kg/d, b.i.d. (GW1) or 8.7 mg/kg/d, q.d. (GW2); topical permethrin (1.3 mg/kg), topical N,N-diethyl-meta-toluamide (33%) and restraint stress (5 min). Animals were phenotypically evaluated as described in an accompanying article [124] and sacrificed at 6.6 months post-treatment (PT) to allow measurement of brain neuroinflammation/neuropathic pain gene expression, hippocampal glial fibrillary acidic protein, brain Interleukin-6, gut dysbiosis and serum endotoxin.<h4>Key findings</h4>Compared"],"journal":["Life sciences"],"pubmed_title":["Induction of distinct neuroinflammatory markers and gut dysbiosis by differential pyridostigmine bromide dosing in a chronic mouse model of GWI showing persistent exercise fatigue and cognitive impairment."],"pmcid":["PMC9048156"],"funding_grant_id":["R01 AI157106","R01 AI153314","R35 GM124724","R01 DK091281","R01 DK130373","R21 AI152017"],"pubmed_authors":["Piamthai V","Carabelli B","McCole DF","Bishay AE","Crawford MS","Curras-Collazo MC","Zur Nieden NI","Denys ME","Liu R","Kozlova EV","Macbeth JC","Hsiao A"],"additional_accession":[]},"is_claimable":false,"name":"Induction of distinct neuroinflammatory markers and gut dysbiosis by differential pyridostigmine bromide dosing in a chronic mouse model of GWI showing persistent exercise fatigue and cognitive impairment.","description":"<h4>Aims</h4>To characterize neuroinflammatory and gut dysbiosis signatures that accompany exaggerated exercise fatigue and cognitive/mood deficits in a mouse model of Gulf War Illness (GWI).<h4>Methods</h4>Adult male C57Bl/6N mice were exposed for 28 d (5 d/wk) to pyridostigmine bromide (P.O.) at 6.5 mg/kg/d, b.i.d. (GW1) or 8.7 mg/kg/d, q.d. (GW2); topical permethrin (1.3 mg/kg), topical N,N-diethyl-meta-toluamide (33%) and restraint stress (5 min). Animals were phenotypically evaluated as described in an accompanying article [124] and sacrificed at 6.6 months post-treatment (PT) to allow measurement of brain neuroinflammation/neuropathic pain gene expression, hippocampal glial fibrillary acidic protein, brain Interleukin-6, gut dysbiosis and serum endotoxin.<h4>Key findings</h4>Compared","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-05-31T21:54:27.529Z","creation":"2024-11-09T12:05:43.036Z"},"accession":"S-EPMC9048156","cross_references":{"pubmed":["34801513"],"doi":["10.1016/j.lfs.2021.120153"]}}