{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu S"],"funding":["NIH HHS"],"pagination":["879152"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9048205"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the cause of the COVID-19 pandemic, is initiated by its binding to the ACE2 receptor and other co-receptors on mucosal epithelial cells. Variable outcomes of the infection and disease severity can be influenced by pre-existing risk factors. Human immunodeficiency virus (HIV), the cause of AIDS, targets the gut mucosal immune system and impairs epithelial barriers and mucosal immunity. We sought to determine the impact and mechanisms of pre-existing HIV infection increasing mucosal vulnerability to SARS-CoV-2 infection and disease. We investigated changes in the expression of ACE2 and other SARS-CoV-2 receptors and related pathways in virally inflamed gut by using the SIV infected rhesus macaque model of HIV/AIDS. I"],"journal":["Frontiers in microbiology"],"pubmed_title":["Altered Expression of ACE2 and Co-receptors of SARS-CoV-2 in the Gut Mucosa of the SIV Model of HIV/AIDS."],"pmcid":["PMC9048205"],"funding_grant_id":["P51 OD011107"],"pubmed_authors":["Hu S","Buser E","Santos Rocha C","Dandekar S","Arredondo J","Relyea D"],"additional_accession":[]},"is_claimable":false,"name":"Altered Expression of ACE2 and Co-receptors of SARS-CoV-2 in the Gut Mucosa of the SIV Model of HIV/AIDS.","description":"The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the cause of the COVID-19 pandemic, is initiated by its binding to the ACE2 receptor and other co-receptors on mucosal epithelial cells. Variable outcomes of the infection and disease severity can be influenced by pre-existing risk factors. Human immunodeficiency virus (HIV), the cause of AIDS, targets the gut mucosal immune system and impairs epithelial barriers and mucosal immunity. We sought to determine the impact and mechanisms of pre-existing HIV infection increasing mucosal vulnerability to SARS-CoV-2 infection and disease. We investigated changes in the expression of ACE2 and other SARS-CoV-2 receptors and related pathways in virally inflamed gut by using the SIV infected rhesus macaque model of HIV/AIDS. I","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T17:47:20.691Z","creation":"2025-04-04T07:55:52.016Z"},"accession":"S-EPMC9048205","cross_references":{"pubmed":["35495669"],"doi":["10.3389/fmicb.2022.879152"]}}