biostudies-literatureLi FChongqing University of EducationChongqing Municipal Education CommissionProgram for Innovation Team Building at Institutions of Higher Education in Chongqing1-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC9048285biostudies-literatureUnknown10(1)This study was conducted to investigate the preventative effect of <i>Lactobacillus fermentum</i> HFY06 on carbon tetrachloride (CCl₄)-induced liver injury in Kunming mice. Mice were treated with HFY06, then liver damage was induced using CCl₄. Evaluation indicators included the activities of aspartate aminotransferase (AST), triglycerides (TG), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) in serum; cytokines levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in serum; and related gene expressions of nuclear factor-κB (NF-κB), TNF-α, cyclooxygenase-2 (COX-2), copper/zinc superoxide dismutase (Cu/Zn-SOD), manganese superoxide dismutase (Mn-SOD), and catalase (CAT). Liver tissue was stained RSC advances<i>Lactobacillus fermentum</i> HFY06 reduced CCl₄-induced hepatic damage in Kunming mice.PMC9048285CXTDX201601040KY201919CKJZD-K201901601Li WZhong QLi FLiao WLu DYTan FZhao Xfalse<i>Lactobacillus fermentum</i> HFY06 reduced CCl₄-induced hepatic damage in Kunming mice.This study was conducted to investigate the preventative effect of <i>Lactobacillus fermentum</i> HFY06 on carbon tetrachloride (CCl₄)-induced liver injury in Kunming mice. Mice were treated with HFY06, then liver damage was induced using CCl₄. Evaluation indicators included the activities of aspartate aminotransferase (AST), triglycerides (TG), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) in serum; cytokines levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in serum; and related gene expressions of nuclear factor-κB (NF-κB), TNF-α, cyclooxygenase-2 (COX-2), copper/zinc superoxide dismutase (Cu/Zn-SOD), manganese superoxide dismutase (Mn-SOD), and catalase (CAT). Liver tissue was stained 2019-01-01T00:00:00Z2019 Dec2025-05-18T12:06:14.762Z2025-04-05T20:38:24.811ZS-EPMC90482853549255310.1039/c9ra08789c