biostudies-literatureMansano Willig JCFundação AraucáriaConselho Nacional de Desenvolvimento Científico e Tecnológico3407-3415https://www.ebi.ac.uk/biostudies/studies/S-EPMC9048522biostudies-literatureUnknown10(6)The catalytic activity of metal-organic framework Cu(INA)<sub>2</sub> (INA = isonicotinate ion) and the complex [Cu(INA)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>] were studied in the Copper-catalyzed Azide-Alkyne Cycloaddition (CuAAC) and Biginelli reaction under solvent-free reaction conditions. The robust, efficient and eco-friendly new method allowed the preparation of a variety of 1,2,3-triazole compounds in good to excellent yields and high selectivity for the 1,4-disubstituted triazole. Moreover, for the Biginelli reaction between aldehydes, ethyl acetoacetate and urea, the corresponding dihydropyrimidinones (DHPMs) were also obtained in satisfactory yields under mild reaction conditions for both catalysts. The comparative study between Cu(INA)<sub>2</sub>-MOF and [Cu(INA)<sub>2</sub>RSC advancesA comparative study between Cu(INA)<sub>2</sub>-MOF and [Cu(INA)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>] complex for a click reaction and the Biginelli reaction under solvent-free conditions.PMC9048522003/2017429831/2018-8Granetto GPoruczinski EFde Oliveira IMde Campos SDDutra FRManarin FStefani HAde Campos EAReginato DMansano Willig JCBotteselle GVfalseA comparative study between Cu(INA)<sub>2</sub>-MOF and [Cu(INA)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>] complex for a click reaction and the Biginelli reaction under solvent-free conditions.The catalytic activity of metal-organic framework Cu(INA)<sub>2</sub> (INA = isonicotinate ion) and the complex [Cu(INA)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>] were studied in the Copper-catalyzed Azide-Alkyne Cycloaddition (CuAAC) and Biginelli reaction under solvent-free reaction conditions. The robust, efficient and eco-friendly new method allowed the preparation of a variety of 1,2,3-triazole compounds in good to excellent yields and high selectivity for the 1,4-disubstituted triazole. Moreover, for the Biginelli reaction between aldehydes, ethyl acetoacetate and urea, the corresponding dihydropyrimidinones (DHPMs) were also obtained in satisfactory yields under mild reaction conditions for both catalysts. The comparative study between Cu(INA)<sub>2</sub>-MOF and [Cu(INA)<sub>2</sub>2020-01-01T00:00:00Z2020 Jan2025-04-04T08:36:24.922Z2024-11-21T02:48:16.648ZS-EPMC90485223549773110.1039/c9ra10171c