biostudies-literatureUnknown10Jiang M<h4>Background</h4>Never-smokers with lung cancer usually have a higher survival rate than that of smokers. The high metabolic activity of lung cancer on ¹⁸F-2-Fluoro-2-deoxyglucose (¹⁸F-FDG) PET/CT generally indicates a poor outcome. However, there is a lack of reports on the association between cigarette smoking and ¹⁸F-FDG metabolic activity in patients with lung cancer. In this study, we aimed to investigate the effects of cigarette smoking on metabolic activity of lung cancer on ¹⁸F-FDG PET/CT.<h4>Materials and methods</h4>A total of 338 patients (230 males, 108 females; mean age: 66.3, range 34-86) with pathologically diagnosed lung cancer were enrolled from September 2019 to April 2021. All patients underwent baseline ¹⁸F-FDG PEPeerJe13352https://www.ebi.ac.uk/biostudies/studies/S-EPMC9048646biostudies-literatureEffects of cigarette smoking on metabolic activity of lung cancer on baseline ¹⁸F-FDG PET/CT.PMC9048646Gao QZheng JMei WZhang JGuo XZhang XJiang MfalseEffects of cigarette smoking on metabolic activity of lung cancer on baseline ¹⁸F-FDG PET/CT.<h4>Background</h4>Never-smokers with lung cancer usually have a higher survival rate than that of smokers. The high metabolic activity of lung cancer on ¹⁸F-2-Fluoro-2-deoxyglucose (¹⁸F-FDG) PET/CT generally indicates a poor outcome. However, there is a lack of reports on the association between cigarette smoking and ¹⁸F-FDG metabolic activity in patients with lung cancer. In this study, we aimed to investigate the effects of cigarette smoking on metabolic activity of lung cancer on ¹⁸F-FDG PET/CT.<h4>Materials and methods</h4>A total of 338 patients (230 males, 108 females; mean age: 66.3, range 34-86) with pathologically diagnosed lung cancer were enrolled from September 2019 to April 2021. All patients underwent baseline ¹⁸F-FDG PE2022-01-01T00:00:00Z20222025-04-04T23:16:01.791Z2025-04-04T23:16:01.791ZS-EPMC90486463549718010.7717/peerj.13352