{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo N"],"funding":["Medical Research Foundation of Guangdong","Discipline Construction Project of Guangdong Medical University","Innovation and Entrepreneurship Team Leads the Pilot Program of Zhanjiang","Guangdong Basic and Applied Basic Research Foundation","Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme"],"pagination":["1086-1099"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9048949"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["The development of novel wound dressings, such as aerogels, with rapid hemostasis and bactericidal capacities for pre-hospital care is necessary. To prevent the occurrence of bacterial resistance, antibacterial photodynamic therapy (aPDT) with broad-spectrum antibacterial ability and negligible bacterial resistance has been intensively studied. However, photosensitizers often suffer from poor water solubility, short singlet oxygen (<sup>1</sup>O<sub>2</sub>) half-life and restricted <sup>1</sup>O<sub>2</sub> diffusion distance. Herein, sodium alginate was covalently modified by photosensitizers and phenylboronic acid, and cross-linked by Ca(II) ions to generate SA@TPAPP@PBA aerogel after lyophilization as an antibacterial photodynamic wound dressing. Afterwards, its photodynamic and bacter"],"journal":["Drug delivery"],"pubmed_title":["Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy."],"pmcid":["PMC9048949"],"funding_grant_id":["4SG21002G","2021A1515010097","A2021121","2020LHJH005"],"pubmed_authors":["Guo N","Xia Y","Li G","Liu Y","Chen J","Huang Z","Wu Q","Wang G","Zeng W","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy.","description":"The development of novel wound dressings, such as aerogels, with rapid hemostasis and bactericidal capacities for pre-hospital care is necessary. To prevent the occurrence of bacterial resistance, antibacterial photodynamic therapy (aPDT) with broad-spectrum antibacterial ability and negligible bacterial resistance has been intensively studied. However, photosensitizers often suffer from poor water solubility, short singlet oxygen (<sup>1</sup>O<sub>2</sub>) half-life and restricted <sup>1</sup>O<sub>2</sub> diffusion distance. Herein, sodium alginate was covalently modified by photosensitizers and phenylboronic acid, and cross-linked by Ca(II) ions to generate SA@TPAPP@PBA aerogel after lyophilization as an antibacterial photodynamic wound dressing. Afterwards, its photodynamic and bacter","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-26T15:14:00.003Z","creation":"2025-04-06T14:53:04.947Z"},"accession":"S-EPMC9048949","cross_references":{"pubmed":["35373683"],"doi":["10.1080/10717544.2022.2058650"]}}