biostudies-literatureGuo NMedical Research Foundation of GuangdongDiscipline Construction Project of Guangdong Medical UniversityInnovation and Entrepreneurship Team Leads the Pilot Program of ZhanjiangGuangdong Basic and Applied Basic Research FoundationGuangdong Province Universities and Colleges Pearl River Scholar Funded Scheme1086-1099https://www.ebi.ac.uk/biostudies/studies/S-EPMC9048949biostudies-literatureUnknown29(1)The development of novel wound dressings, such as aerogels, with rapid hemostasis and bactericidal capacities for pre-hospital care is necessary. To prevent the occurrence of bacterial resistance, antibacterial photodynamic therapy (aPDT) with broad-spectrum antibacterial ability and negligible bacterial resistance has been intensively studied. However, photosensitizers often suffer from poor water solubility, short singlet oxygen (¹O₂) half-life and restricted ¹O₂ diffusion distance. Herein, sodium alginate was covalently modified by photosensitizers and phenylboronic acid, and cross-linked by Ca(II) ions to generate SA@TPAPP@PBA aerogel after lyophilization as an antibacterial photodynamic wound dressing. Afterwards, its photodynamic and bacterDrug deliveryAlginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy.PMC90489494SG21002G2021A1515010097A20211212020LHJH005Guo NXia YLi GLiu YChen JHuang ZWu QWang GZeng WShi YfalseAlginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy.The development of novel wound dressings, such as aerogels, with rapid hemostasis and bactericidal capacities for pre-hospital care is necessary. To prevent the occurrence of bacterial resistance, antibacterial photodynamic therapy (aPDT) with broad-spectrum antibacterial ability and negligible bacterial resistance has been intensively studied. However, photosensitizers often suffer from poor water solubility, short singlet oxygen (¹O₂) half-life and restricted ¹O₂ diffusion distance. Herein, sodium alginate was covalently modified by photosensitizers and phenylboronic acid, and cross-linked by Ca(II) ions to generate SA@TPAPP@PBA aerogel after lyophilization as an antibacterial photodynamic wound dressing. Afterwards, its photodynamic and bacter2022-01-01T00:00:00Z2022 Dec2025-04-26T15:14:00.003Z2025-04-06T14:53:04.947ZS-EPMC90489493537368310.1080/10717544.2022.2058650