{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao Y"],"funding":["Conseil Régional de Picardie","Seventh Framework Programme","European Regional Development Fund"],"pagination":["5978-5987"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9049337"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(10)"],"pubmed_abstract":["Degradable molecularly imprinted polymers (MIPs) with affinity for <i>S</i>-propranolol were prepared by the copolymerization of methacrylic acid as functional monomer and a disulfide-containing cross-linker, bis(2-methacryloyloxyethyl)disulfide (DSDMA), using bulk polymerization or high dilution polymerization for nanogels synthesis. The specificity and the selectivity of DSDMA-based molecularly imprinted polymers toward <i>S</i>-propranolol were studied in batch binding experiments, and their binding properties were compared to a traditional ethylene glycol dimethacrylate (EDMA)-based MIP. Nanosized MIPs prepared with DSDMA as crosslinker could be degraded into lower molecular weight linear polymers by cleaving the disulfide bonds and thus reversing cross-linking using different reducing agents (NaBH<sub>4</sub>, DTT, GSH). Turbidity, viscosity, polymer size and IR-spectra were measured to study the polymer degradation. The loss of specific recognition and binding capacity of <i>S</i>-propranolol was also observed after MIP degradation. This phenomenon was applied to modulate the release properties of the MIP. In presence of GSH at its intracellular concentration, the <i>S</i>-propranolol release was higher, showing that these materials could potentially be applied as intracellular controlled drug delivery system."],"journal":["RSC advances"],"pubmed_title":["Reduction-responsive molecularly imprinted nanogels for drug delivery applications."],"pmcid":["PMC9049337"],"funding_grant_id":["Marie Curie Programme ITN CHEBANA"],"pubmed_authors":["Falcimaigne-Cordin A","Daoud Attieh M","Haupt K","Zhao Y","Simon C"],"additional_accession":[]},"is_claimable":false,"name":"Reduction-responsive molecularly imprinted nanogels for drug delivery applications.","description":"Degradable molecularly imprinted polymers (MIPs) with affinity for <i>S</i>-propranolol were prepared by the copolymerization of methacrylic acid as functional monomer and a disulfide-containing cross-linker, bis(2-methacryloyloxyethyl)disulfide (DSDMA), using bulk polymerization or high dilution polymerization for nanogels synthesis. The specificity and the selectivity of DSDMA-based molecularly imprinted polymers toward <i>S</i>-propranolol were studied in batch binding experiments, and their binding properties were compared to a traditional ethylene glycol dimethacrylate (EDMA)-based MIP. Nanosized MIPs prepared with DSDMA as crosslinker could be degraded into lower molecular weight linear polymers by cleaving the disulfide bonds and thus reversing cross-linking using different reducing agents (NaBH<sub>4</sub>, DTT, GSH). Turbidity, viscosity, polymer size and IR-spectra were measured to study the polymer degradation. The loss of specific recognition and binding capacity of <i>S</i>-propranolol was also observed after MIP degradation. This phenomenon was applied to modulate the release properties of the MIP. In presence of GSH at its intracellular concentration, the <i>S</i>-propranolol release was higher, showing that these materials could potentially be applied as intracellular controlled drug delivery system.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2025-04-04T08:20:59.074Z","creation":"2025-02-18T23:21:20.116Z"},"accession":"S-EPMC9049337","cross_references":{"pubmed":["35497405"],"doi":["10.1039/c9ra07512g"]}}