{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ariantari NP"],"funding":["Deutscher Akademischer Austauschdienst","Deutsche Forschungsgemeinschaft","Jürgen Manchot Stiftung"],"pagination":["7232-7240"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9049863"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(12)"],"pubmed_abstract":["Didymellanosine (1), the first analogue of the decahydrofluorene-class of natural products bearing a 13-membered macrocyclic alkaloid conjugated with adenosine, and a new benzolactone derivative, ascolactone C (4) along with eight known compounds (2, 3, 5-10), were isolated from a solid rice fermentation of the endophytic fungus <i>Didymella</i> sp. IEA-3B.1 derived from the host plant <i>Terminalia catappa</i>. In addition, ascochitamine (11) was obtained when (NH<sub>4</sub>)<sub>2</sub>SO<sub>4</sub> was added to rice medium and is reported here for the first time as a natural product. Didymellanosine (1) displayed strong activity against the murine lymphoma cell line L5178Y, Burkitt's lymphoma B cells (Ramos) and adult lymphoblastic leukemia T cells (Jurkat J16), with IC<sub>50</sub> v"],"journal":["RSC advances"],"pubmed_title":["Didymellanosine, a new decahydrofluorene analogue, and ascolactone C from <i>Didymella</i> sp. IEA-3B.1, an endophyte of <i>Terminalia catappa</i>."],"pmcid":["PMC9049863"],"funding_grant_id":["270650915/GRK 2158"],"pubmed_authors":["Teusch N","Muller WEG","Reimche I","Ariantari NP","Ancheeva E","Groner Y","Meier D","Liu Z","Wesselborg S","Kalscheuer R","Frank M","Stuhldreier F","Proksch P"],"additional_accession":[]},"is_claimable":false,"name":"Didymellanosine, a new decahydrofluorene analogue, and ascolactone C from <i>Didymella</i> sp. IEA-3B.1, an endophyte of <i>Terminalia catappa</i>.","description":"Didymellanosine (1), the first analogue of the decahydrofluorene-class of natural products bearing a 13-membered macrocyclic alkaloid conjugated with adenosine, and a new benzolactone derivative, ascolactone C (4) along with eight known compounds (2, 3, 5-10), were isolated from a solid rice fermentation of the endophytic fungus <i>Didymella</i> sp. IEA-3B.1 derived from the host plant <i>Terminalia catappa</i>. In addition, ascochitamine (11) was obtained when (NH<sub>4</sub>)<sub>2</sub>SO<sub>4</sub> was added to rice medium and is reported here for the first time as a natural product. Didymellanosine (1) displayed strong activity against the murine lymphoma cell line L5178Y, Burkitt's lymphoma B cells (Ramos) and adult lymphoblastic leukemia T cells (Jurkat J16), with IC<sub>50</sub> v","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2026-05-31T06:06:18.985Z","creation":"2025-02-19T01:55:30.119Z"},"accession":"S-EPMC9049863","cross_references":{"pubmed":["35493894"],"doi":["10.1039/c9ra10685e"]}}