{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fedorowski A"],"funding":["NIA NIH HHS"],"pagination":["e010573"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9049902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(3)"],"pubmed_abstract":["Orthostatic hypotension (OH), a common, often overlooked, disorder with many causes, is associated with debilitating symptoms, falls, syncope, cognitive impairment, and risk of death. Chronic OH, a cardinal sign of autonomic dysfunction, increases with advancing age and is commonly associated with neurodegenerative and autoimmune diseases, diabetes, hypertension, heart failure, and kidney failure. Management typically involves a multidisciplinary, patient-centered, approach to arrive at an appropriate underlying diagnosis that is causing OH, treating accompanying conditions, and providing individually tailored pharmacological and nonpharmacological treatment. We propose a novel streamlined pathophysiological classification of OH; review the relationship between the cardiovascular disease continuum and OH; discuss OH-mediated end-organ damage; provide diagnostic and therapeutic algorithms to guide clinical decision making and patient care; identify current gaps in knowledge and try to define future research directions. Using a case-based learning approach, specific clinical scenarios are presented highlighting various presentations of OH to provide a practical guide to evaluate and manage patients who have OH."],"journal":["Circulation. Arrhythmia and electrophysiology"],"pubmed_title":["Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem."],"pmcid":["PMC9049902"],"funding_grant_id":["K08 AG058483"],"pubmed_authors":["Sandau KE","Hamrefors V","Ricci F","Gopinathannair R","Fedorowski A","Muldowney JAS","Olshansky B","Hwan Chung T"],"additional_accession":[]},"is_claimable":false,"name":"Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem.","description":"Orthostatic hypotension (OH), a common, often overlooked, disorder with many causes, is associated with debilitating symptoms, falls, syncope, cognitive impairment, and risk of death. Chronic OH, a cardinal sign of autonomic dysfunction, increases with advancing age and is commonly associated with neurodegenerative and autoimmune diseases, diabetes, hypertension, heart failure, and kidney failure. Management typically involves a multidisciplinary, patient-centered, approach to arrive at an appropriate underlying diagnosis that is causing OH, treating accompanying conditions, and providing individually tailored pharmacological and nonpharmacological treatment. We propose a novel streamlined pathophysiological classification of OH; review the relationship between the cardiovascular disease continuum and OH; discuss OH-mediated end-organ damage; provide diagnostic and therapeutic algorithms to guide clinical decision making and patient care; identify current gaps in knowledge and try to define future research directions. Using a case-based learning approach, specific clinical scenarios are presented highlighting various presentations of OH to provide a practical guide to evaluate and manage patients who have OH.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T06:45:53.882Z","creation":"2025-04-19T06:45:53.882Z"},"accession":"S-EPMC9049902","cross_references":{"pubmed":["35212554"],"doi":["10.1161/circep.121.010573","10.1161/CIRCEP.121.010573"]}}