{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li M"],"funding":["Suzhou Municipal Science and Technology Bureau"],"pagination":["2009724"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9050282"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["<h4>Background</h4>Tenascin-C (TNC), an extracellular matrix glycoprotein, is elevated in inflammatory and cardiovascular pathologies, whereas alarin, a novel orexigenic peptide, participates in insulin resistance and glycometabolism. The roles of these molecules in individuals with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), clinical conditions associating with metabolic disorders, and chronic inflammation, remain controversial. Our study aimed at determining the potential role of TNC and alarin in CVD adult patients with T2DM.<h4>Methods</h4>This was a cross-sectional study. Basic and clinical information for 250 patients with T2DM were analyzed. Based on their cardiovascular disease status, participants were assigned into the CVD and non-CVD groups. Serum TNC and a"],"journal":["International journal of endocrinology"],"pubmed_title":["Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus."],"pmcid":["PMC9050282"],"funding_grant_id":["SS202008","81800714","SYS2020103","SLT202008"],"pubmed_authors":["Hua Y","Wu M","Yao J","Shi B","Zhu H","Ma Z","Feng B","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus.","description":"<h4>Background</h4>Tenascin-C (TNC), an extracellular matrix glycoprotein, is elevated in inflammatory and cardiovascular pathologies, whereas alarin, a novel orexigenic peptide, participates in insulin resistance and glycometabolism. The roles of these molecules in individuals with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), clinical conditions associating with metabolic disorders, and chronic inflammation, remain controversial. Our study aimed at determining the potential role of TNC and alarin in CVD adult patients with T2DM.<h4>Methods</h4>This was a cross-sectional study. Basic and clinical information for 250 patients with T2DM were analyzed. Based on their cardiovascular disease status, participants were assigned into the CVD and non-CVD groups. Serum TNC and a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T23:15:26.08Z","creation":"2025-04-04T23:15:26.08Z"},"accession":"S-EPMC9050282","cross_references":{"pubmed":["35493201"],"doi":["10.1155/2022/2009724"]}}