{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Y"],"funding":["NCATS NIH HHS","NIAID NIH HHS"],"pagination":["110829"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9050581"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(7)"],"pubmed_abstract":["We report that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant replacement during the coronavirus disease 2019 (COVID-19) pandemic. Delta SARS-CoV-2 efficiently outcompetes the Alpha variant in human lung epithelial cells and primary human airway tissues. The Delta spike mutation P681R is located at a furin cleavage site that separates the spike 1 (S1) and S2 subunits. Reverting the P681R mutation to wild-type P681 significantly reduces the replication of the Delta variant to a level lower than the Alpha variant. Mechanistically, the Delta P681R mutation enhances the cleavage of the full-length spike to S1 and S2, which could improve cell-surface-mediated virus entry. In contrast, the Alpha spike also ha"],"journal":["Cell reports"],"pubmed_title":["Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant."],"pmcid":["PMC9050581"],"funding_grant_id":["U01 AI151801","R01 AI153602","R21 AI145400","HHSN272201600013C","UL1 TR001439","R24 AI120942"],"pubmed_authors":["Liu Y","Xia H","Liu J","Johnson BA","Widen SG","Weaver SC","Xie X","Ku Z","An Z","Shi PY","Schindewolf C","Menachery VD"],"additional_accession":[]},"is_claimable":false,"name":"Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.","description":"We report that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant replacement during the coronavirus disease 2019 (COVID-19) pandemic. Delta SARS-CoV-2 efficiently outcompetes the Alpha variant in human lung epithelial cells and primary human airway tissues. The Delta spike mutation P681R is located at a furin cleavage site that separates the spike 1 (S1) and S2 subunits. Reverting the P681R mutation to wild-type P681 significantly reduces the replication of the Delta variant to a level lower than the Alpha variant. Mechanistically, the Delta P681R mutation enhances the cleavage of the full-length spike to S1 and S2, which could improve cell-surface-mediated virus entry. In contrast, the Alpha spike also ha","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-30T20:54:12.112Z","creation":"2025-04-04T10:01:51.965Z"},"accession":"S-EPMC9050581","cross_references":{"pubmed":["35550680"],"doi":["10.1016/j.celrep.2022.110829"]}}