{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li L"],"funding":["NIAID NIH HHS","Medical Research Council","NHLBI NIH HHS","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["658-669"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9050758"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(5)"],"pubmed_abstract":["<h4>Background</h4>Little is known about the association of newborn DNA methylation (DNAm) with asthma acquisition across adolescence and early adult life.<h4>Objective</h4>We aim to identify epigenetic biomarkers in newborns for asthma acquisition during adolescence or young adulthood.<h4>Methods</h4>The Isle of Wight Birth Cohort (IOWBC) (n = 1456) data at ages 10, 18 and 26 years were assessed. To screen cytosine-phosphate-guanine site (CpGs) potentially associated with asthma acquisition, at the genome scale, we examined differentially methylated regions (DMR) using dmrff R package and individual CpG sites using linear regression on such associations. For CpGs that passed screening, we examined their enrichment in biological pathways using their mapping genes and tested their associati"],"journal":["Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology"],"pubmed_title":["Newborn DNA methylation and asthma acquisition across adolescence and early adulthood."],"pmcid":["PMC9050758"],"funding_grant_id":["R01 AI091905","G9815508","217065/Z/19/Z","BB/I025263/1","R01 HL132321","R01 AI121226","MC_PC_19009","MC_PC_15018","MC_UU_00011/5"],"pubmed_authors":["Arshad SH","Karmaus W","Zhang H","Relton CL","Holloway JW","Li L","Ewart S"],"additional_accession":[]},"is_claimable":false,"name":"Newborn DNA methylation and asthma acquisition across adolescence and early adulthood.","description":"<h4>Background</h4>Little is known about the association of newborn DNA methylation (DNAm) with asthma acquisition across adolescence and early adult life.<h4>Objective</h4>We aim to identify epigenetic biomarkers in newborns for asthma acquisition during adolescence or young adulthood.<h4>Methods</h4>The Isle of Wight Birth Cohort (IOWBC) (n = 1456) data at ages 10, 18 and 26 years were assessed. To screen cytosine-phosphate-guanine site (CpGs) potentially associated with asthma acquisition, at the genome scale, we examined differentially methylated regions (DMR) using dmrff R package and individual CpG sites using linear regression on such associations. For CpGs that passed screening, we examined their enrichment in biological pathways using their mapping genes and tested their associati","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-06-04T05:00:10.907Z","creation":"2025-04-06T17:20:10.002Z"},"accession":"S-EPMC9050758","cross_references":{"pubmed":["34995380"],"doi":["10.1111/cea.14091"]}}