{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Medeiros MC"],"funding":["NIDCR NIH HHS","National Institute of Dental and Craniofacial Research","Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["241-256"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9050779"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(2)"],"pubmed_abstract":["<h4>Purpose</h4>Galanin receptor 2 (GALR2) plays a significant role in the progression of head and neck squamous cell carcinomas (HNSCC). Since there is virtually no information on immunomodulation mediated by its ligand in the tumor microenvironment, we assessed the effects of galanin on peripheral blood mononuclear cells (PBMCs).<h4>Methods</h4>After verification of GALR2 expression and it activity in PBMCs we evaluated the effect of galanin and conditioned media from HNSCC cell lines silenced for galanin or antibody-depleted, on proliferation, apoptosis, cytokine expression and activation/differentiation of immune cells.<h4>Results</h4>We found that galanin alone and as a component of the HNSCC secretome decreased HNSCC cell proliferation and expression of pro-inflammatory cytokines (IF"],"journal":["Cellular oncology (Dordrecht, Netherlands)"],"pubmed_title":["Galanin mediates tumor-induced immunosuppression in head and neck squamous cell carcinoma."],"pmcid":["PMC9050779"],"funding_grant_id":["R35 DE027551","2014/50312-4 ; 2014/16436-5; 2014/06472-4 ; 2013/16487-6, 2017/14283-5","DE027551"],"pubmed_authors":["Banerjee R","Rossa C","Liu M","Bellile E","de Medeiros MC","D'Silva NJ"],"additional_accession":[]},"is_claimable":false,"name":"Galanin mediates tumor-induced immunosuppression in head and neck squamous cell carcinoma.","description":"<h4>Purpose</h4>Galanin receptor 2 (GALR2) plays a significant role in the progression of head and neck squamous cell carcinomas (HNSCC). Since there is virtually no information on immunomodulation mediated by its ligand in the tumor microenvironment, we assessed the effects of galanin on peripheral blood mononuclear cells (PBMCs).<h4>Methods</h4>After verification of GALR2 expression and it activity in PBMCs we evaluated the effect of galanin and conditioned media from HNSCC cell lines silenced for galanin or antibody-depleted, on proliferation, apoptosis, cytokine expression and activation/differentiation of immune cells.<h4>Results</h4>We found that galanin alone and as a component of the HNSCC secretome decreased HNSCC cell proliferation and expression of pro-inflammatory cytokines (IF","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-07-14T17:07:36.153Z","creation":"2025-04-06T02:38:39.143Z"},"accession":"S-EPMC9050779","cross_references":{"pubmed":["35267186"],"doi":["10.1007/s13402-021-00631-y"]}}