biostudies-literatureUnknown10(28)Lemahieu GFive new bio-based surfactants have been synthetized by coupling hexahydrofarnesol with mono and di-saccharides. Hexahydrofarnesol (3,7,11-trimethyl-dodecan-1-ol) is a by-product of the industrial production of farnesane, a sustainable aviation fuel obtained by a fermentation process from sugar feedstocks. Using hexahydrofarnesol as the lipophilic starting material allows obtaining 100% bio-based surfactants while valorizing an industrial by-product. Moreover, the C₁₅-branched alkyl chain brings unique properties to the surfactants. This paper presents a physicochemical characterization of these new surfactants including their behaviors in water (water solubility, critical micellar concentration and surface tension) and in oil/water systems (interfacial tension against model oilRSC advances16377-16389https://www.ebi.ac.uk/biostudies/studies/S-EPMC9052940biostudies-literatureHexahydrofarnesyl as an original bio-sourced alkyl chain for the preparation of glycosides surfactants with enhanced physicochemical properties.PMC9052940Aguilhon JOntiveros JFAubry JMMolinier VStrub HLemahieu GfalseHexahydrofarnesyl as an original bio-sourced alkyl chain for the preparation of glycosides surfactants with enhanced physicochemical properties.Five new bio-based surfactants have been synthetized by coupling hexahydrofarnesol with mono and di-saccharides. Hexahydrofarnesol (3,7,11-trimethyl-dodecan-1-ol) is a by-product of the industrial production of farnesane, a sustainable aviation fuel obtained by a fermentation process from sugar feedstocks. Using hexahydrofarnesol as the lipophilic starting material allows obtaining 100% bio-based surfactants while valorizing an industrial by-product. Moreover, the C₁₅-branched alkyl chain brings unique properties to the surfactants. This paper presents a physicochemical characterization of these new surfactants including their behaviors in water (water solubility, critical micellar concentration and surface tension) and in oil/water systems (interfacial tension against model oil2020-01-01T00:00:00Z2020 Apr2025-05-18T12:06:38.491Z2025-04-04T07:31:40.18ZS-EPMC90529403549883910.1039/d0ra02326d