{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Q"],"funding":["National Basic Research Program of China","Fundamental Research Funds for the Central Universities","National Natural Science Foundation of China"],"pagination":["16537-16550"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9052948"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(28)"],"pubmed_abstract":["Osseointegration at the bone-implant interface is a complex biological process that is triggered by the immune-inflammatory response and mediated by various cell types such as, bone-forming cells and immune cells, especially macrophages. The polarization of macrophages to inflammatory/regenerative (M1/M2) phenotypes, as well as the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) at the bone-implant interface, significantly affects implant osseointegration and even causes implant failure. Graphene oxide (GO) is a promising candidate for performing implant surface functionalization to modulate the interactions between implants and cells. Herein, we explored the effects of a GO coating on the osteogenic differentiation of BMSCs and the polarization of macrophages to e"],"journal":["RSC advances"],"pubmed_title":["Enhanced osteogenic differentiation of BMSCs and M2-phenotype polarization of macrophages on a titanium surface modified with graphene oxide for potential implant applications."],"pmcid":["PMC9052948"],"funding_grant_id":["2018YFE0202200","81670962","20152957","81271110"],"pubmed_authors":["Shen A","Li Q","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Enhanced osteogenic differentiation of BMSCs and M2-phenotype polarization of macrophages on a titanium surface modified with graphene oxide for potential implant applications.","description":"Osseointegration at the bone-implant interface is a complex biological process that is triggered by the immune-inflammatory response and mediated by various cell types such as, bone-forming cells and immune cells, especially macrophages. The polarization of macrophages to inflammatory/regenerative (M1/M2) phenotypes, as well as the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) at the bone-implant interface, significantly affects implant osseointegration and even causes implant failure. Graphene oxide (GO) is a promising candidate for performing implant surface functionalization to modulate the interactions between implants and cells. Herein, we explored the effects of a GO coating on the osteogenic differentiation of BMSCs and the polarization of macrophages to e","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-04-04T09:10:08.084Z","creation":"2025-04-04T09:10:08.084Z"},"accession":"S-EPMC9052948","cross_references":{"pubmed":["35498860"],"doi":["10.1039/c9ra10563h"]}}