{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1"],"submitter":["Ying K"],"pubmed_abstract":["<h4>Background</h4>Epidemiological studies revealed that the elderly and those with comorbidities are most affected by COVID-19, but it is important to investigate shared genetic mechanisms between COVID-19 risk and aging.<h4>Methods</h4>We conducted a multi-instrument Mendelian Randomization analysis of multiple lifespan-related traits and COVID-19. Aging clock models were applied to the subjects with different COVID-19 conditions in the UK-Biobank cohort. We performed a bivariate genomic scan for age-related COVID-19 and Mendelian Randomization analysis of 389 immune cell traits to investigate their effect on lifespan and COVID-19 risk.<h4>Results</h4>We show that the genetic variation that supports longer life is significantly associated with the lower risk of COVID-19 infection and hospitalization. The odds ratio is 0.31 (<i>P</i> = 9.7 × 10<sup>-6</sup>) and 0.46 (<i>P</i> = 3.3 × 10<sup>-4</sup>), respectively, per additional 10 years of life. We detect an association between biological age acceleration and future incidence and severity of COVID-19 infection. Genetic profiling of age-related COVID-19 infection indicates key contributions of Notch signaling and immune system development. We reveal a negative correlation between the effects of immune cell traits on lifespan and COVID-19 risk. We find that lower B-cell CD19 levels are indicative of an increased risk of COVID-19 and decreased life expectancy, which is further validated by COVID-19 clinical data.<h4>Conclusions</h4>Our analysis suggests that the factors that accelerate aging lead to an increased COVID-19 risk and point to the importance of Notch signaling and B cells in both. Interventions that target these factors to reduce biological age may reduce the risk of COVID-19."],"journal":["Communications medicine"],"pagination":["35"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9053191"],"repository":["biostudies-literature"],"pubmed_title":["Genetic and phenotypic analysis of the causal relationship between aging and COVID-19."],"pmcid":["PMC9053191"],"pubmed_authors":["Zhai R","Gladyshev VN","Shindyapina AV","Pyrkov TV","Fedichev PO","Shen X","Ying K","Mariotti M"],"additional_accession":[]},"is_claimable":false,"name":"Genetic and phenotypic analysis of the causal relationship between aging and COVID-19.","description":"<h4>Background</h4>Epidemiological studies revealed that the elderly and those with comorbidities are most affected by COVID-19, but it is important to investigate shared genetic mechanisms between COVID-19 risk and aging.<h4>Methods</h4>We conducted a multi-instrument Mendelian Randomization analysis of multiple lifespan-related traits and COVID-19. Aging clock models were applied to the subjects with different COVID-19 conditions in the UK-Biobank cohort. We performed a bivariate genomic scan for age-related COVID-19 and Mendelian Randomization analysis of 389 immune cell traits to investigate their effect on lifespan and COVID-19 risk.<h4>Results</h4>We show that the genetic variation that supports longer life is significantly associated with the lower risk of COVID-19 infection and hospitalization. The odds ratio is 0.31 (<i>P</i> = 9.7 × 10<sup>-6</sup>) and 0.46 (<i>P</i> = 3.3 × 10<sup>-4</sup>), respectively, per additional 10 years of life. We detect an association between biological age acceleration and future incidence and severity of COVID-19 infection. Genetic profiling of age-related COVID-19 infection indicates key contributions of Notch signaling and immune system development. We reveal a negative correlation between the effects of immune cell traits on lifespan and COVID-19 risk. We find that lower B-cell CD19 levels are indicative of an increased risk of COVID-19 and decreased life expectancy, which is further validated by COVID-19 clinical data.<h4>Conclusions</h4>Our analysis suggests that the factors that accelerate aging lead to an increased COVID-19 risk and point to the importance of Notch signaling and B cells in both. Interventions that target these factors to reduce biological age may reduce the risk of COVID-19.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2024-11-09T20:54:33.385Z","creation":"2024-11-09T20:54:33.385Z"},"accession":"S-EPMC9053191","cross_references":{"pubmed":["35602207"],"doi":["10.1038/s43856-021-00033-z"]}}