biostudies-literatureWickham RJNIMH NIH HHSA28-A39https://www.ebi.ac.uk/biostudies/studies/S-EPMC9053429biostudies-literatureUnknown20(1)Course-based undergraduate research experiences (CUREs) are increasingly common approaches to provide students with authentic laboratory experiences. Typically, CUREs are semester-long, in-person experiences that can be financially and time prohibitive for some institutions, faculty, and students. Here, we developed a short-duration, fully-online CURE, the Spine Lab, to provide an opportunity for students to conduct original research. In this CURE, we focused on synaptic spines in the mammalian brain; synapses are the unit structure that functions in rapid information processing. The students worked together in pairs and as a class to analyze cortical neuron spine density and structural morphology changes between a mouse line with learning impairments (forebrain-specific β-catenin knockoutJournal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate NeuroscienceThe Spine Lab: A Short-Duration, Fully-Remote Course-Based Undergraduate Research Experience.PMC9053429R01 MH106623Jacob MHGenne-Bacon EAWickham RJfalseThe Spine Lab: A Short-Duration, Fully-Remote Course-Based Undergraduate Research Experience.Course-based undergraduate research experiences (CUREs) are increasingly common approaches to provide students with authentic laboratory experiences. Typically, CUREs are semester-long, in-person experiences that can be financially and time prohibitive for some institutions, faculty, and students. Here, we developed a short-duration, fully-online CURE, the Spine Lab, to provide an opportunity for students to conduct original research. In this CURE, we focused on synaptic spines in the mammalian brain; synapses are the unit structure that functions in rapid information processing. The students worked together in pairs and as a class to analyze cortical neuron spine density and structural morphology changes between a mouse line with learning impairments (forebrain-specific β-catenin knockout2021-01-01T00:00:00Z20212025-04-04T09:10:17.988Z2025-02-19T03:24:55.745ZS-EPMC905342935540947