{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(20)"],"submitter":["Kishor G"],"pubmed_abstract":["An efficient, transition metal-free visible-light-driven continuous-flow C-3-alkylation of quinoxalin-2(1<i>H</i>)-ones has been demonstrated by employing Katritzky salts as alkylating agents in the presence of eosin-y as a photoredox catalyst and DIPEA as a base at room temperature. The present protocol was accomplished by utilizing abundant and inexpensive alkyl amine (both primary and secondary alkyl) and as well as this a few amino acid feedstocks were converted into their corresponding redox-active pyridinium salts and subsequently into alkyl radicals. A wide variety of C-3-alkylated quinoxalin-2(1<i>H</i>)-ones were synthesized in moderate to high yields. Further this environmentally benign protocol is carried out in a PFA (Perfluoroalkoxy alkane) capillary based micro reactor under "],"journal":["RSC advances"],"pagination":["12235-12241"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9053435"],"repository":["biostudies-literature"],"pubmed_title":["Regioselective C-3-alkylation of quinoxalin-2(1<i>H</i>)-ones <i>via</i> C-N bond cleavage of amine derived Katritzky salts enabled by continuous-flow photoredox catalysis."],"pmcid":["PMC9053435"],"pubmed_authors":["Ramesh V","Pabbaraja S","Rao VR","Kishor G","Adiyala PR"],"additional_accession":[]},"is_claimable":false,"name":"Regioselective C-3-alkylation of quinoxalin-2(1<i>H</i>)-ones <i>via</i> C-N bond cleavage of amine derived Katritzky salts enabled by continuous-flow photoredox catalysis.","description":"An efficient, transition metal-free visible-light-driven continuous-flow C-3-alkylation of quinoxalin-2(1<i>H</i>)-ones has been demonstrated by employing Katritzky salts as alkylating agents in the presence of eosin-y as a photoredox catalyst and DIPEA as a base at room temperature. The present protocol was accomplished by utilizing abundant and inexpensive alkyl amine (both primary and secondary alkyl) and as well as this a few amino acid feedstocks were converted into their corresponding redox-active pyridinium salts and subsequently into alkyl radicals. A wide variety of C-3-alkylated quinoxalin-2(1<i>H</i>)-ones were synthesized in moderate to high yields. Further this environmentally benign protocol is carried out in a PFA (Perfluoroalkoxy alkane) capillary based micro reactor under ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T21:33:27.771Z","creation":"2025-04-04T21:33:27.771Z"},"accession":"S-EPMC9053435","cross_references":{"pubmed":["35517836"],"doi":["10.1039/d2ra00753c"]}}