biostudies-literatureUnknown12(20)Kishor GAn efficient, transition metal-free visible-light-driven continuous-flow C-3-alkylation of quinoxalin-2(1<i>H</i>)-ones has been demonstrated by employing Katritzky salts as alkylating agents in the presence of eosin-y as a photoredox catalyst and DIPEA as a base at room temperature. The present protocol was accomplished by utilizing abundant and inexpensive alkyl amine (both primary and secondary alkyl) and as well as this a few amino acid feedstocks were converted into their corresponding redox-active pyridinium salts and subsequently into alkyl radicals. A wide variety of C-3-alkylated quinoxalin-2(1<i>H</i>)-ones were synthesized in moderate to high yields. Further this environmentally benign protocol is carried out in a PFA (Perfluoroalkoxy alkane) capillary based micro reactor under RSC advances12235-12241https://www.ebi.ac.uk/biostudies/studies/S-EPMC9053435biostudies-literatureRegioselective C-3-alkylation of quinoxalin-2(1<i>H</i>)-ones <i>via</i> C-N bond cleavage of amine derived Katritzky salts enabled by continuous-flow photoredox catalysis.PMC9053435Ramesh VPabbaraja SRao VRKishor GAdiyala PRfalseRegioselective C-3-alkylation of quinoxalin-2(1<i>H</i>)-ones <i>via</i> C-N bond cleavage of amine derived Katritzky salts enabled by continuous-flow photoredox catalysis.An efficient, transition metal-free visible-light-driven continuous-flow C-3-alkylation of quinoxalin-2(1<i>H</i>)-ones has been demonstrated by employing Katritzky salts as alkylating agents in the presence of eosin-y as a photoredox catalyst and DIPEA as a base at room temperature. The present protocol was accomplished by utilizing abundant and inexpensive alkyl amine (both primary and secondary alkyl) and as well as this a few amino acid feedstocks were converted into their corresponding redox-active pyridinium salts and subsequently into alkyl radicals. A wide variety of C-3-alkylated quinoxalin-2(1<i>H</i>)-ones were synthesized in moderate to high yields. Further this environmentally benign protocol is carried out in a PFA (Perfluoroalkoxy alkane) capillary based micro reactor under 2022-01-01T00:00:00Z2022 Apr2025-04-04T21:33:27.771Z2025-04-04T21:33:27.771ZS-EPMC90534353551783610.1039/d2ra00753c