biostudies-literatureUnknown10(30)Ali HRHIn recent decades, H₂O₂ has been promoted as a health indicator because its moderate to high levels can cause some health problems. Herein, we developed a new fluorescent nanoprobe for rapid, selective and sensitive detection of H₂O₂. The fluorescent nanoprobe is composed of fluorescein dye (FLS) as a fluorescent probe and MnO₂ nanosheets (MnO₂ NS) as a quencher. In this study, H₂O₂ can reduce MnO₂ NS in the synthesized composite and release FLS, causing sufficient recovery of fluorescent signal related to the concentration of H₂O₂. The nanoprobe, with <i>λ</i> _ex/<i>λ</i> _em at 495/515 nm, has a linear range of 0.04-30 μM, with a limit of detectionRSC advances17506-17514https://www.ebi.ac.uk/biostudies/studies/S-EPMC9053515biostudies-literatureOne pot fabrication of fluorescein functionalized manganese dioxide for fluorescence "Turn OFF-ON" sensing of hydrogen peroxide in water and cosmetic samples.PMC9053515Hassan YFEl-Wekil MMHassan AIAli HRHfalseOne pot fabrication of fluorescein functionalized manganese dioxide for fluorescence "Turn OFF-ON" sensing of hydrogen peroxide in water and cosmetic samples.In recent decades, H₂O₂ has been promoted as a health indicator because its moderate to high levels can cause some health problems. Herein, we developed a new fluorescent nanoprobe for rapid, selective and sensitive detection of H₂O₂. The fluorescent nanoprobe is composed of fluorescein dye (FLS) as a fluorescent probe and MnO₂ nanosheets (MnO₂ NS) as a quencher. In this study, H₂O₂ can reduce MnO₂ NS in the synthesized composite and release FLS, causing sufficient recovery of fluorescent signal related to the concentration of H₂O₂. The nanoprobe, with <i>λ</i> _ex/<i>λ</i> _em at 495/515 nm, has a linear range of 0.04-30 μM, with a limit of detection2020-01-01T00:00:00Z2020 May2025-06-01T12:02:56.731Z2024-11-20T14:08:15.985ZS-EPMC90535153551559610.1039/d0ra01980a