biostudies-literatureUnknown10(30)Duflocq SOne-pot oxime ligation under mild conditions using Pd(ii) as a shared catalyst from an aldehyde precursor (Thz) and a protected aminooxyacetyl group (Proc-Aoa) is reported. Two complementary metal-free protocols using unmasked Aoa-peptide are also described. Acetoxime-peptide can proceed to the desired oxime through an additional transoximation step.RSC advances17681-17685https://www.ebi.ac.uk/biostudies/studies/S-EPMC9053634biostudies-literatureOne-pot oxime ligation from peptides bearing thiazolidine and aminooxyacetyl groups.PMC9053634Duflocq SHuguenot FVidal MZhou JLiu WQfalseOne-pot oxime ligation from peptides bearing thiazolidine and aminooxyacetyl groups.One-pot oxime ligation under mild conditions using Pd(ii) as a shared catalyst from an aldehyde precursor (Thz) and a protected aminooxyacetyl group (Proc-Aoa) is reported. Two complementary metal-free protocols using unmasked Aoa-peptide are also described. Acetoxime-peptide can proceed to the desired oxime through an additional transoximation step.2020-01-01T00:00:00Z2020 May2025-05-18T12:06:46.699Z2025-04-06T19:14:20.659ZS-EPMC90536343551561610.1039/d0ra03235b