biostudies-literatureUnknown16Gross IFAZIT StiftungDuring adult neurogenesis, neuronal stem cells differentiate into mature neurons that are functionally integrated into the existing network. One hallmark during the late phase of this neurodifferentiation process is the formation of dendritic spines. These morphological specialized structures form the basis of most excitatory synapses in the brain, and are essential for neuronal communication. Additionally, dendritic spines are affected in neurological disorders, such as Alzheimer's disease or schizophrenia. However, the mechanisms underlying spinogenesis, as well as spine pathologies, are poorly understood. Plasticity-related Gene 5 (PRG5), a neuronal transmembrane protein, has previously been linked to spinogenesis <i>in vitro</i>. Here, we analyze endogenous expression of the PRG5 proteFrontiers in cellular neuroscience797588https://www.ebi.ac.uk/biostudies/studies/S-EPMC9053830biostudies-literaturePlasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination.PMC9053830Heep ABrauer AURabus RWohlbrand LPlosch TGross IKoper FVonk DBrandt NWitt MHipp MSfalsePlasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination.During adult neurogenesis, neuronal stem cells differentiate into mature neurons that are functionally integrated into the existing network. One hallmark during the late phase of this neurodifferentiation process is the formation of dendritic spines. These morphological specialized structures form the basis of most excitatory synapses in the brain, and are essential for neuronal communication. Additionally, dendritic spines are affected in neurological disorders, such as Alzheimer's disease or schizophrenia. However, the mechanisms underlying spinogenesis, as well as spine pathologies, are poorly understood. Plasticity-related Gene 5 (PRG5), a neuronal transmembrane protein, has previously been linked to spinogenesis <i>in vitro</i>. Here, we analyze endogenous expression of the PRG5 prote2022-01-01T00:00:00Z20222026-05-31T21:55:46.93Z2025-02-19T03:27:33.358ZS-EPMC90538303549690810.3389/fncel.2022.797588