{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(36)"],"submitter":["Shah SR"],"pubmed_abstract":["We have successfully developed a flexible green aqueous approach for the formation of a carbon-carbon bond by the reaction of highly-enolizable carbanions (mostly derived from 1,3-dicarbonyl compounds) with an aromatic carbon bearing a nitro group. The key step involves a nucleophilic displacement reaction. All newly synthesized compounds were unambiguously characterized <i>via</i> various spectroscopic techniques including NMR, mass spectrometry and single-crystal X-ray diffraction as applicable. We believe that our study will be useful in providing new insights into catalyst-free water-mediated nucleophilic substitution reactions."],"journal":["RSC advances"],"pagination":["21656-21661"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9054563"],"repository":["biostudies-literature"],"pubmed_title":["A highly green approach towards aromatic nitro group substitutions: catalyst free reactions of nitroimidazoles with carbon nucleophiles in water."],"pmcid":["PMC9054563"],"pubmed_authors":["Shah SR","Al-Harrasi A","Anwar MU","Ali M"],"additional_accession":[]},"is_claimable":false,"name":"A highly green approach towards aromatic nitro group substitutions: catalyst free reactions of nitroimidazoles with carbon nucleophiles in water.","description":"We have successfully developed a flexible green aqueous approach for the formation of a carbon-carbon bond by the reaction of highly-enolizable carbanions (mostly derived from 1,3-dicarbonyl compounds) with an aromatic carbon bearing a nitro group. The key step involves a nucleophilic displacement reaction. All newly synthesized compounds were unambiguously characterized <i>via</i> various spectroscopic techniques including NMR, mass spectrometry and single-crystal X-ray diffraction as applicable. We believe that our study will be useful in providing new insights into catalyst-free water-mediated nucleophilic substitution reactions.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-22T01:39:08.309Z","creation":"2025-04-05T20:05:39.919Z"},"accession":"S-EPMC9054563","cross_references":{"pubmed":["35518760"],"doi":["10.1039/d0ra03640d"]}}