biostudies-literatureUnknown10(36)Shah SRWe have successfully developed a flexible green aqueous approach for the formation of a carbon-carbon bond by the reaction of highly-enolizable carbanions (mostly derived from 1,3-dicarbonyl compounds) with an aromatic carbon bearing a nitro group. The key step involves a nucleophilic displacement reaction. All newly synthesized compounds were unambiguously characterized <i>via</i> various spectroscopic techniques including NMR, mass spectrometry and single-crystal X-ray diffraction as applicable. We believe that our study will be useful in providing new insights into catalyst-free water-mediated nucleophilic substitution reactions.RSC advances21656-21661https://www.ebi.ac.uk/biostudies/studies/S-EPMC9054563biostudies-literatureA highly green approach towards aromatic nitro group substitutions: catalyst free reactions of nitroimidazoles with carbon nucleophiles in water.PMC9054563Shah SRAl-Harrasi AAnwar MUAli MfalseA highly green approach towards aromatic nitro group substitutions: catalyst free reactions of nitroimidazoles with carbon nucleophiles in water.We have successfully developed a flexible green aqueous approach for the formation of a carbon-carbon bond by the reaction of highly-enolizable carbanions (mostly derived from 1,3-dicarbonyl compounds) with an aromatic carbon bearing a nitro group. The key step involves a nucleophilic displacement reaction. All newly synthesized compounds were unambiguously characterized <i>via</i> various spectroscopic techniques including NMR, mass spectrometry and single-crystal X-ray diffraction as applicable. We believe that our study will be useful in providing new insights into catalyst-free water-mediated nucleophilic substitution reactions.2020-01-01T00:00:00Z2020 Jun2025-04-22T01:39:08.309Z2025-04-05T20:05:39.919ZS-EPMC90545633551876010.1039/d0ra03640d