{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["111(5)"],"submitter":["Lip GYH"],"funding":["Boehringer Ingelheim"],"pubmed_abstract":["<h4>Background and purpose</h4>Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF).<h4>Methods</h4>In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest.<h4>Results</h4>The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014"],"journal":["Clinical research in cardiology : official journal of the German Cardiac Society"],"pagination":["560-573"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9054878"],"repository":["biostudies-literature"],"pubmed_title":["Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry."],"pmcid":["PMC9054878"],"pubmed_authors":["Frandsen B","Rashba E","Ronner E","Quintana AG","Mikdadi G","Manterola FA","Giniger A","Forman S","Hernandes ME","Laboulle B","Watanabe K","Caccavo A","Matsuda K","Kawai K","Manning R","Davy JM","Kotalczyk A","Streb W","Kovacic D","de Paola AAV","Van Eck M","Davalos V","Augenbraun C","Healey J","Leitao A","Smith DW","Kurrelmeyer K","Bartlett M","May E","Hulsman 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Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF).<h4>Methods</h4>In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest.<h4>Results</h4>The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-07-14T16:44:37.874Z","creation":"2025-04-05T22:17:03.686Z"},"accession":"S-EPMC9054878","cross_references":{"pubmed":["35294625"],"doi":["10.1007/s00392-022-01996-2"]}}