biostudies-literatureUnknown111(5)Lip GYHBoehringer Ingelheim<h4>Background and purpose</h4>Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF).<h4>Methods</h4>In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest.<h4>Results</h4>The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014Clinical research in cardiology : official journal of the German Cardiac Society560-573https://www.ebi.ac.uk/biostudies/studies/S-EPMC9054878biostudies-literatureComparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry.PMC9054878Frandsen BRashba ERonner EQuintana AGMikdadi GManterola FAGiniger AForman SHernandes MELaboulle BWatanabe KCaccavo AMatsuda KKawai KManning RDavy JMKotalczyk AStreb WKovacic Dde Paola AAVVan Eck MDavalos VAugenbraun CHealey JLeitao ASmith DWKurrelmeyer KBartlett MMay EHulsman ELBhatta LPetkar SAiub JRKazmierski JFRubalcava FSeamark CSchnupp SBuhl AGillespie EKafkala KWei JJouve BTse HFZahn RBerti SLuke RFauchier LVincent MHahalis GRuiz ROKeeling PHalperin JLSaraiva JFKLee CHYamashita TBongiorni MGMarchionni NMont LChatterjee KVera TRFavale SD'Souza ACovalesky JDong QJose EPGunther AFerreira LGGNor AMVillamil ALandau CSarikonda KCha TJNazlic JValenzuela EJJRCHermosillo JAGChen LPersic VSime IGeorger FVallejo GSMartinez JPollock SSalacata ACullen TMalhotra RZizzo SWiggers PTesloianu DOikonomou KDauber ICabrera JWHou YKoh SMAAudouin PFerro HMori KGorka HPerez BGorog DYeh KHVelasco JAASerrati CStoddard MMilicic DFerrier ALinares JAda Costa Darrieux FCVera YCDZarich SMa CMercader MGadsboll NHwang GSMa GSasaoka TGarcea JPChrysos DShah NHemels MKashou HMirault TShah SSheikh KHKrenning BJLeschke MEbels-Tuinbeek LAPatrick JKaufman ESchmitz LAlonso DHearne SKetova GHakas JDefaye PShah VDuygun ASofley CPengo VNeykova ASteinwender CJoen-Jakobsen TEaton CBCalvi VBerz ABloch MJHorbach SFahmy RGronda ELo EDos Santos FRGmehling JMibach FTamm AHong SKSavelieva IKuniss MBottacchi EGuevara CBoswijk DJAziz ELopez VMGSpyropoulos ACGammelgaard ASeidman BMiarka JThomas DBohmer EHan SNica NCPeters TKHernandez NMYotov YBank AMinaie SJenkins RDVlastaris AShaw LBergler-Klein JWozakowska-Kaplon BCardona FBando SHan BWeiner SSchmitz BLupovitch SFonseca CMazuecos JBBlack TZeuthen ELLavandier KLelonek MCaine SIyer VGniot JScala PJHuckins DTveit AKrikke FBradman DJattin FMCalo LMichel PProtasov KDubner SJDeepak SFumagalli SDe Franceschi TBuenostro GCStiell IBagni ESalem AChiang FTKrause LGoldbarg SCary SEaves WBerrospi PAmmirati FProdafikas JVora KSibilio GGu XGalinier MBrouwers PJAMMuriago MMcClure JShahawy MEMainigi SKOliver RLam YYGaneshkumar PGoudevenos IShah Avan Bergen PFMMMayer NKwak CHDe Biasio MSoda HAliyar PJames MAguilar FCarreno SRaev DCandeias RCrea FEsquivias GBShin DGRauch-Kroehnert UAddala SShin ESFarsad Rvan de Borne PEsperon GLFirst BPalomino MMohammed AZimmermann SHenein SPajes GMakaritsis KLin HVictory JAinsworth PWilke AGuignier AGoube PNegron SAIrles DCampos RNKamo TMeno HDi Legge SFragoso JCNVial HCelentano AConti AMintale IBlumberg EKim DIRanieri MBott JChae JKSanchez CJWu RCKim DKNsah EChiarella FLey NLellouche NRutgers MPSchnabel TTakagi YAyryanova INechvatal LNageh TRahimi SQiu ZDubrey SZenin SSearles GHill MRieker WArora CMeyer CChandrashekar HMcGarity Wde Los Rios Ibarra MOIkpoh MNayak HMLi WJones NLi XNyvad OLi ZRubacek MMeyer BJWunderlich SCompton SLanna Figueiredo ELyrer PNurgalieva SBetzu RCarvalho PPineau JMunoz FDDe Bonis SIzal AESaid SHa AMadariaga IWeinrich RKragten JASek JO'Donnell PFilho AMLCollins RSparby JAKampus PZhao SPShite JLuo MKromhout ZZhang XO'Donnell MGomez SRothman KJFruntelata AGPaz AZhang DZhang JPivac NZhang HTorosoff MDeumite NJZhang PMiguel RNde la Pena Topete GSanchez MCO'Hara GLehman JFischer SZheng YHermany PChallappa KYin WHLeong-Sit PDavies RAnsalone GMusumeci FDziewas RHargrove JSantana AMDoukky RHendriks IColivicchi FFerri CIseki HBest EAguinaga LKamali FHeffernan MZhou JJarmukli NKachkovskiy MPerlman RFerreira JBenedetti RRodriguez RHLSilver FMikus MHurtado HAMAydin SHuang CHOlympios CKoide SLenderink TKumar PPhillips RTDietz DGoldberg RGrado CARCarolei AGraham BSeidl KHSchmitz KHSun XHeijmeriks JAFriedman KYang TGabra NMirro MJTsai WKLam ALeBlanc JSchon NZukerman LOh SMinescu BRaposo NBullinga JFrench WSalvioni ADe La Briolle ADe Caterina RVeerareddy SAnnoni GFriese AOh DCortada JBHaruna TInce HStakos DAlmeida LFMollerus MTer Lai WRenda Gvan der Zwaan CNakagawa HPye MMilitaru CDotcheva EKhaira ASTurner WVenkataraman AWylie JYan YSOTakhar APSXu XXu YMaskova PNowalany-Kozielska ERozkova NFinsen ASchoeniger PCapuano VMondillo SGartenlaub OWong BPrecoma DBChow DHLopez AChreih RMKmetzo JJCasu GMaurer TNaydenov SHong KAdragao PMiyamoto NAlvaro FMaqueda VMiu NVRickli HMusser CWVester EGJabali AEKlein ASekaran LMulhearn TJManolis AVersaci FTu TMDionisio PRaisaro ADavis GRizo TCVerdecchia PBloom SRitt LEGremmler ULieber IPflucke CMoschos NAbdul NLuengas CAReddy RWen MSTeutsch CMistry DCrenshaw JNakamura YChen SALorraine RSPinter ALiu HBrowne KDucrocq XTrendafilova ESukles KTimsit 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CTobaru TKuppers ABernstein RAHung KCCai SDe Horta JWakefield PRichter DJung KTMaeno KBackes LMBaula GNatarajan IVanacker PMaid GKrysiak WGlotzer TVSimmers TAMoniz PBell AThe SHKMusial WSchwimmbeck PPadilla FGPPark JSRama BGierba MNizov APandey ASRybak KPorcu MMontagud VDascotte OTorres IGTGkotsis APark HWPham DNOrtega IGCislowski DJHughes KVasilyev MStyliadis IKinova ELee MHChoi DJAsensi JOTayebjee MPentz WTuininga YMarler SChand SPBuathier HEichinger-Hasenauer SWong KSLFernandez MSAriani MKDary PAggarwal RTang ADarius HTassinari Tde Groot JRCavallini CKastrup ACrean PTouze EFayard MTang SSpinar JMontana OMugge APocanic DTanaka KDupljakov DAlexopoulos DSotolongo RNam GBBrautigam DZong WQuedillac JMAdams FEvonich RGuardigli Gde Souza OFKhripun ARamos RBala RJung WPoppert HGoldmann Bde Souza WGeorgeson SKoziolova NHigashino YMichalski DGrena PGPrasad NWang FJorge JCMWang MWang NShimomura HLopez-Sendon JLGrond MWang TWu SPerticone FWang XRoman MTomasik ARDuque MSales JCGurusamy VKTsutsui HAndrawis NLip GYHBrunschwig CJimenez RPTurk SPinto FCha KSMenzies DHsing JAmara WKraft PPodoleanu CIndolfi CHer SHGLORIA-AF InvestigatorsArias JCKneller GLFilho DSPieters DBhagwat RHoriuchi MGaspardone AKostis WJBisignani GLandini GNechita ACBaldi ATurakhia MGoethals PMorka JHuizinga AKim YHDiener HCReza SFundamenski MMoschini LMagnin DOrtuno FMBanerjee SSati HChoi JISaporito WFHoghton MKowalczyk JDe Wolf LSiostrzonek PAbud AMDahl JVJimenez JKatsivas ABodes RSFang QEisenberg SJSaltzman MAOmaszuk-Kazberuk AfalseComparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry.<h4>Background and purpose</h4>Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF).<h4>Methods</h4>In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest.<h4>Results</h4>The GLORIA-AF Phase III registry enrolled 21,300 patients between January 20142022-01-01T00:00:00Z2022 May2026-07-14T16:44:37.874Z2025-04-05T22:17:03.686ZS-EPMC90548783529462510.1007/s00392-022-01996-2