biostudies-literatureUnknown10(40)Wang YDIsochaetoglobosin D_b is a new chaetoglobosin possessing a unique 3,4-substituted pyrrole ring isolated and named by Qiu <i>et al.</i>, and it is different from any one of the 14 sub-types in the macrocyclic ring of chaetoglobosins classified in our previous work. Its chemical shift values, coupling constants and biosynthetic consideration implied that the proposed structure of isochaetoglobosin D_b was incorrect. In this report, based on detailed NMR data analysis together with biosynthetic consideration, the structure of isochaetoglobosin D_b is suggested to be revised to that of penochalasin C. The NMR spectra of penochalasin C measured in the same solvent (DMSO-<i>d</i> ₆) as that of isochaetoglobosin D_b supported the above conclusionRSC advances23969-23974https://www.ebi.ac.uk/biostudies/studies/S-EPMC9055075biostudies-literatureRevision of the structure of isochaetoglobosin D_b based on NMR analysis and biosynthetic consideration.PMC9055075Shen LDing GTan XMChen LWang YDWei ZQLi YYfalseRevision of the structure of isochaetoglobosin D_b based on NMR analysis and biosynthetic consideration.Isochaetoglobosin D_b is a new chaetoglobosin possessing a unique 3,4-substituted pyrrole ring isolated and named by Qiu <i>et al.</i>, and it is different from any one of the 14 sub-types in the macrocyclic ring of chaetoglobosins classified in our previous work. Its chemical shift values, coupling constants and biosynthetic consideration implied that the proposed structure of isochaetoglobosin D_b was incorrect. In this report, based on detailed NMR data analysis together with biosynthetic consideration, the structure of isochaetoglobosin D_b is suggested to be revised to that of penochalasin C. The NMR spectra of penochalasin C measured in the same solvent (DMSO-<i>d</i> ₆) as that of isochaetoglobosin D_b supported the above conclusion2020-01-01T00:00:00Z2020 Jun2025-04-18T15:44:32.298Z2024-11-14T03:49:33.131ZS-EPMC90550753551736310.1039/d0ra04108d