{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun W"],"funding":["Chinese Academy of Sciences","National Key R&amp;D Program of China","National Natural Science Foundation of China"],"pagination":["25364-25369"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9055273"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(42)"],"pubmed_abstract":["Fluorination in enhancing photoactivated antibacterial activity of Ru(ii) complexes with photo-labile ligands was studied. Ru(ii) polypyridine complexes containing a di-fluorinated dppz (dipyrido[3,2-<i>a</i>:2',3'-<i>c</i>]phenazine) or mono-trifluoromethylated dppz bidentate ligand and four pyridine monodentate ligands (complexes 3 and 4) were found to show potent photoactivated antibacterial activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), vancomycin-resistant <i>Enterococcus</i> (VRE), and <i>Escherichia coli</i> (<i>E. coli</i>) in both normoxic and hypoxic conditions. The bactericidal effect of complexes 3 and 4 under hypoxic conditions may stem from the fluorine-containing Ru(ii) aqua species after photo-induced pyridine dissociation, and DNA may be the po"],"journal":["RSC advances"],"pubmed_title":["Fluorination in enhancing photoactivated antibacterial activity of Ru(ii) complexes with photo-labile ligands."],"pmcid":["PMC9055273"],"funding_grant_id":["XDB17000000","2018YFC1602204","21390400, 21571181, and 21773277"],"pubmed_authors":["Boerhan R","Zhou Q","Feng Y","Lu J","Sun W","Wang X","Tian N"],"additional_accession":[]},"is_claimable":false,"name":"Fluorination in enhancing photoactivated antibacterial activity of Ru(ii) complexes with photo-labile ligands.","description":"Fluorination in enhancing photoactivated antibacterial activity of Ru(ii) complexes with photo-labile ligands was studied. Ru(ii) polypyridine complexes containing a di-fluorinated dppz (dipyrido[3,2-<i>a</i>:2',3'-<i>c</i>]phenazine) or mono-trifluoromethylated dppz bidentate ligand and four pyridine monodentate ligands (complexes 3 and 4) were found to show potent photoactivated antibacterial activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), vancomycin-resistant <i>Enterococcus</i> (VRE), and <i>Escherichia coli</i> (<i>E. coli</i>) in both normoxic and hypoxic conditions. The bactericidal effect of complexes 3 and 4 under hypoxic conditions may stem from the fluorine-containing Ru(ii) aqua species after photo-induced pyridine dissociation, and DNA may be the po","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-18T14:14:52.87Z","creation":"2025-04-07T00:19:11.429Z"},"accession":"S-EPMC9055273","cross_references":{"pubmed":["35517482"],"doi":["10.1039/d0ra01806f"]}}