biostudies-literatureIllan-Gala INIA NIH HHSe229588https://www.ebi.ac.uk/biostudies/studies/S-EPMC9055455biostudies-literatureUnknown5(4)<h4>Importance</h4>The accurate diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) is hampered by imperfect clinical-pathological correlations.<h4>Objective</h4>To assess and compare the diagnostic value of the magnetic resonance parkinsonism index (MRPI) and other magnetic resonance imaging-based measures of cerebral atrophy to differentiate between PSP, CBD, and other neurodegenerative diseases.<h4>Design, setting, and participants</h4>This prospective diagnostic study included participants with 4-repeat tauopathies (4RT), PSP, CBD, other neurodegenerative diseases and available MRI who appeared in the University of California, San Francisco, Memory and Aging Center database. Data were collected from October 27, 1994, to September 29, 2019. Data were anJAMA network openDiagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration.PMC9055455R01 AG062758P01 AG019724R01 AG059794K08 AG052648Miller BLFalgas NSpina SRosen HJPainous CKulisevsky JPagonabarraga JBoxer ALLa Joie RRabinovici GDPerry DCVandeVrede LLogroscino GGrinberg LTNigro SFortea JGorno-Tempini MLCompta YIllan-Gala IMarti MJMontal VLleo ARojas JCQuattrone ASeeley WWHeuer HWfalseDiagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration.<h4>Importance</h4>The accurate diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) is hampered by imperfect clinical-pathological correlations.<h4>Objective</h4>To assess and compare the diagnostic value of the magnetic resonance parkinsonism index (MRPI) and other magnetic resonance imaging-based measures of cerebral atrophy to differentiate between PSP, CBD, and other neurodegenerative diseases.<h4>Design, setting, and participants</h4>This prospective diagnostic study included participants with 4-repeat tauopathies (4RT), PSP, CBD, other neurodegenerative diseases and available MRI who appeared in the University of California, San Francisco, Memory and Aging Center database. Data were collected from October 27, 1994, to September 29, 2019. Data were an2022-01-01T00:00:00Z2022 Apr2025-04-04T21:33:44.5Z2025-02-19T01:23:56.456ZS-EPMC90554553548639710.1001/jamanetworkopen.2022.9588