biostudies-literatureQin LDepartment of Science and Technology of Sichuan Province28397-28407https://www.ebi.ac.uk/biostudies/studies/S-EPMC9055648biostudies-literatureUnknown10(47)Porous β-tricalcium phosphate (β-Ca₃(PO₄)₂, β-TCP) scaffolds are widely applied in the field of bone tissue engineering due to their nontoxicity, degradability, biocompatibility, and osteoinductivity. However, poor compressive strength and a lack of antibacterial properties have hindered their clinical application. In order to address these disadvantages, graphene (G) and silver nanoparticles were introduced into β-TCP through a two-step method. In the synthesis process, G-β-TCP was prepared <i>via</i> an <i>in situ</i> synthesis method, and then silver nanoparticles and HAp particles were coated on the surface of the G-β-TCP scaffold in an orderly fashion using dopamine as a binder. From the results of characterization, when the content of graphene was 1 wRSC advancesThe preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties.PMC90556482019YJ0141Yi JKenan XQin LLu XXuefei LLi LfalseThe preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties.Porous β-tricalcium phosphate (β-Ca₃(PO₄)₂, β-TCP) scaffolds are widely applied in the field of bone tissue engineering due to their nontoxicity, degradability, biocompatibility, and osteoinductivity. However, poor compressive strength and a lack of antibacterial properties have hindered their clinical application. In order to address these disadvantages, graphene (G) and silver nanoparticles were introduced into β-TCP through a two-step method. In the synthesis process, G-β-TCP was prepared <i>via</i> an <i>in situ</i> synthesis method, and then silver nanoparticles and HAp particles were coated on the surface of the G-β-TCP scaffold in an orderly fashion using dopamine as a binder. From the results of characterization, when the content of graphene was 1 w2020-01-01T00:00:00Z2020 Jul2025-04-04T21:31:28.428Z2024-10-15T07:24:47.057ZS-EPMC90556483551912010.1039/d0ra02388d