{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(49)"],"submitter":["Okita H"],"pubmed_abstract":["Stereoselective and efficient synthesis of Gly-Gly-type (<i>E</i>)-methylalkene and (<i>Z</i>)-chloroalkene dipeptide isosteres is realized by organocuprate-mediated single electron transfer reduction. The synthetic isosteres can be used in Fmoc-based solid phase peptide synthesis, resulting in the preparation of the 14-mer RGG peptidomimetics containing an (<i>E</i>)-methylalkene or a (<i>Z</i>)-chloroalkene unit."],"journal":["RSC advances"],"pagination":["29373-29377"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9055925"],"repository":["biostudies-literature"],"pubmed_title":["Stereoselective synthesis of Gly-Gly-type (<i>E</i>)-methylalkene and (<i>Z</i>)-chloroalkene dipeptide isosteres and their application to 14-mer RGG peptidomimetics."],"pmcid":["PMC9055925"],"pubmed_authors":["Okita H","Kato Y","Narumi T","Mase N","Masuzawa T","Arai K","Sato K","Oyoshi T","Takeo S"],"additional_accession":[]},"is_claimable":false,"name":"Stereoselective synthesis of Gly-Gly-type (<i>E</i>)-methylalkene and (<i>Z</i>)-chloroalkene dipeptide isosteres and their application to 14-mer RGG peptidomimetics.","description":"Stereoselective and efficient synthesis of Gly-Gly-type (<i>E</i>)-methylalkene and (<i>Z</i>)-chloroalkene dipeptide isosteres is realized by organocuprate-mediated single electron transfer reduction. The synthetic isosteres can be used in Fmoc-based solid phase peptide synthesis, resulting in the preparation of the 14-mer RGG peptidomimetics containing an (<i>E</i>)-methylalkene or a (<i>Z</i>)-chloroalkene unit.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-06T19:45:22.57Z","creation":"2025-04-06T19:45:22.57Z"},"accession":"S-EPMC9055925","cross_references":{"pubmed":["35521116"],"doi":["10.1039/d0ra06554d"]}}