{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim K"],"funding":["National Research Foundation of Korea","Chung-Ang University"],"pagination":["31101-31105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9056348"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(52)"],"pubmed_abstract":["A facile access to fused pyrimidin-4(3<i>H</i>)-one derivatives has been established by using the metal-free <i>ortho</i>-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra™) in a highly convergent manner."],"journal":["RSC advances"],"pubmed_title":["<i>ortho</i>-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3<i>H</i>)-ones: a convergent synthetic route to bouchardatine and sildenafil."],"pmcid":["PMC9056348"],"funding_grant_id":["NRF-2019R1A2C2089953","NRF-2015R1A5A1008958"],"pubmed_authors":["Oh K","Kim HY","Kim K"],"additional_accession":[]},"is_claimable":false,"name":"<i>ortho</i>-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3<i>H</i>)-ones: a convergent synthetic route to bouchardatine and sildenafil.","description":"A facile access to fused pyrimidin-4(3<i>H</i>)-one derivatives has been established by using the metal-free <i>ortho</i>-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra™) in a highly convergent manner.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-05T00:28:19.059Z","creation":"2024-10-15T07:29:01.637Z"},"accession":"S-EPMC9056348","cross_references":{"pubmed":["35520643"],"doi":["10.1039/d0ra06820a"]}}