biostudies-literatureKim KNational Research Foundation of KoreaChung-Ang University31101-31105https://www.ebi.ac.uk/biostudies/studies/S-EPMC9056348biostudies-literatureUnknown10(52)A facile access to fused pyrimidin-4(3<i>H</i>)-one derivatives has been established by using the metal-free <i>ortho</i>-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra™) in a highly convergent manner.RSC advances<i>ortho</i>-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3<i>H</i>)-ones: a convergent synthetic route to bouchardatine and sildenafil.PMC9056348NRF-2019R1A2C2089953NRF-2015R1A5A1008958Oh KKim HYKim Kfalse<i>ortho</i>-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3<i>H</i>)-ones: a convergent synthetic route to bouchardatine and sildenafil.A facile access to fused pyrimidin-4(3<i>H</i>)-one derivatives has been established by using the metal-free <i>ortho</i>-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra™) in a highly convergent manner.2020-01-01T00:00:00Z2020 Aug2025-04-05T00:28:19.059Z2024-10-15T07:29:01.637ZS-EPMC90563483552064310.1039/d0ra06820a