biostudies-literatureUnknown39(5)Gentile S<h4>Introduction</h4>The history of insulin-induced skin lipohypertrophy (LH) runs parallel to that of insulin's 100 years, and an average of 47% of insulin-treated patients still suffer from it today. The metabolic and economic effects of LH are significant, with hypoglycemia being the most striking. The objective of the study was to perform a 52-week follow-up of 713 insulin-treated patients with type 2 diabetes (T2DM) and LH to detect any differences in the occurrence of hypoglycemic events (HYPOs) and related healthcare costs as well as in LH rates and injection habits between an intensive education intervention group (IG) and control group (CG) provided with a single educational session at the starting point.<h4>Methods</h4>All participants were trained in accurately self-monitoring bAdvances in therapy2192-2207https://www.ebi.ac.uk/biostudies/studies/S-EPMC9056437biostudies-literatureThe Economic Burden of Insulin Injection-Induced Lipohypertophy. Role of Education: The ISTERP-3 Study.PMC9056437Di Riso MRusso ERusso FPagano TD'Errico AVendemia PMenna ECrisci FGBoccia PMigliaccio SPasquarella MApuzzo RFerraro OYushkova ODi Virgilio EIsola FMCesarini TBotta AFabozzi MApuzzo GErbaggio GLatte GCozzolino GMonica EDBarbuto GBartiromo APiccolo FGladka RToscano MESilvestri IBianco VAuletta ACherillo AD'Angelo RMorrone TDi Stazio EGrussu MCasaburo APazdior TJDi Maio RReggio RDi Maio MRiccio ED'Elia CDi Maio GDe Maio AVitale PDi Monte MVitale MLamberti RRiccio RTammaro FFestinese MCorigliano MSavino FATabacco CCorigliano GBiondillo PSpinoso GLamberti CRiccardi BCastellano TAngrisani MDi Matola APassa VGiovanni MSchettino ARepola EMattiello GImbimbo CPuce MDella-Corte TImbimbo MEsca SLoiacono FFinelli MFRomano MMiano PCucco LTroncone ERuotolo ERomano GIacobitti GEDoriano DRomano CStile EVLADel Piano CBattipaglia MLa Rocca CJeschke BRoselli MOcchio ADe Filippis AManzi ELa Manna AMGuerra ALettieri DAlfarone CDi Leva LAmbrosino LCarrara TPina CBarbaro FFiorenza GPalmiero AGarrapa GStasio AMannato DSatta EDel Prete CDella Corte TGuerri MCipriano SCiotta AIacono FLFranco LCaso SFargnoli RGrassi GCimmarosa ACalabrese GPalmeri DDecostanzo APastore APellino ACaracciolo CBrancario CBarrella GCesarano MANatale MTMartino CMarano CAlbertini PDe Vita MANapolitano TSiani MCicala MBrusco OD'Esculapio VMatusz ZSiani AAmodio MGigante CGallo MVela FCirillo CDi Nardo AVetrano AMorgillo VBottiglieri LMontesarchio CTonutti LBrida MGentile SErrichiello RLetizia ODe-Rosa NCicchella MPolichetti COliviero SSalsano ACicchella EOliva DBuono FBernardo RPandolfo AFontanella FManzo LIndaco GPostiglione SVariselli FConturso TRainone AGiove CIzzo AMarino GBuonocore GDonnarumma AAcquaviva MDe Chiara MSchettino DNefrocenter and Nyx Start-up, AMDOSDI Study Group on Injection Techniques, and ANIADDe Micco LScarpati LComo PBosco ASelleri ABranca MPettinati VBuonocore ZBassi AMurano AFSpallieri PSpeese KAmicone MCapece MFerrante PGiordano LAmoroso RVUmmarino GFasolino ARicuperati AGuarino GVecchiato ABorghesi FMilano SDe Felice SDe-Riu SRaffaele ACupic IMonte GMaietta DGiovanna MLACrispino ABelardo OErpete LEsposito VIannone AMandato AMEsposito ROrropesa LFiglioli CMignone ABuska HEsposito GStrollo FChianese GPalmentola GAlfrone CFusco MCapasso MEbraico EDe Lucia MCimmino SImbembo LCampolattano IYavorskiy PPetrone EMalgorzata JMfalseThe Economic Burden of Insulin Injection-Induced Lipohypertophy. Role of Education: The ISTERP-3 Study.<h4>Introduction</h4>The history of insulin-induced skin lipohypertrophy (LH) runs parallel to that of insulin's 100 years, and an average of 47% of insulin-treated patients still suffer from it today. The metabolic and economic effects of LH are significant, with hypoglycemia being the most striking. The objective of the study was to perform a 52-week follow-up of 713 insulin-treated patients with type 2 diabetes (T2DM) and LH to detect any differences in the occurrence of hypoglycemic events (HYPOs) and related healthcare costs as well as in LH rates and injection habits between an intensive education intervention group (IG) and control group (CG) provided with a single educational session at the starting point.<h4>Methods</h4>All participants were trained in accurately self-monitoring b2022-01-01T00:00:00Z2022 May2025-06-01T02:21:40.025Z2024-11-14T19:57:51.328ZS-EPMC90564373530663310.1007/s12325-022-02105-5