biostudies-literatureUnknown10(59)Chandra Sau MThe Nakamura reaction using a cationic cobalt(iii) complex, [Cp*Co(CH₃CN)₃][SbF₆]₂ as the catalyst under neutral and aerobic conditions at 110 °C has been described. In solution, the complex is expected to lose a hemilabile acetonitrile ligand to produce a highly electron-deficient cobalt(iii) center, and the Lewis acidic nature of the cobalt center has been exploited for the enolization of the dicarbonyl compounds. The reaction of 1,3-dicarbonyl compounds with alkynes affords the corresponding alkenyl derivative. However, the reaction of phenylacetylene and its derivatives with β-ketoesters affords corresponding terphenyl compounds. Details of the mechanisms of the reactions have been proposed based on <i>in situ</i> LCMS measurements.RSC advances36014-36019https://www.ebi.ac.uk/biostudies/studies/S-EPMC9056990biostudies-literatureAddition of 1,3-dicarbonyl compounds to terminal alkynes catalyzed by a cationic cobalt(iii) complex.PMC9056990Chandra Sau MBhattacharjee MfalseAddition of 1,3-dicarbonyl compounds to terminal alkynes catalyzed by a cationic cobalt(iii) complex.The Nakamura reaction using a cationic cobalt(iii) complex, [Cp*Co(CH₃CN)₃][SbF₆]₂ as the catalyst under neutral and aerobic conditions at 110 °C has been described. In solution, the complex is expected to lose a hemilabile acetonitrile ligand to produce a highly electron-deficient cobalt(iii) center, and the Lewis acidic nature of the cobalt center has been exploited for the enolization of the dicarbonyl compounds. The reaction of 1,3-dicarbonyl compounds with alkynes affords the corresponding alkenyl derivative. However, the reaction of phenylacetylene and its derivatives with β-ketoesters affords corresponding terphenyl compounds. Details of the mechanisms of the reactions have been proposed based on <i>in situ</i> LCMS measurements.2020-01-01T00:00:00Z2020 Sep2024-11-21T02:48:52.71Z2024-11-21T02:48:52.71ZS-EPMC90569903551710510.1039/d0ra05923d