{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(64)"],"submitter":["Keshavarz H"],"pubmed_abstract":["In clinical applications, chemotherapy and hyperthermia are commonly used together. To achieve this, we synthesized multifunctional magnetite mesoporous silica nanoparticles (MMSNs) coated with a chitosan hydrogel. pH-Responsive chitosan hydrogels (cross-linked glutaraldehyde) were used to cover mesoporous silica pores. The infrared spectroscopy (FT-IR) and electron microscopy images (SEM and TEM) confirm that a hydrogel layer and a silica shell were formed. By applying alternating magnetic fields (AMF) to nanogels, heat generation (43 °C) occurred within a short time. The drug release (tamoxifen) of nanogels was studied for 72 h at different pH and temperatures. Drug release at pH 7.4/<i>T</i> = 37 °C (simulating physiological condition) and pH 5/<i>T</i> = 43 °C (pH simulating endosomes/"],"journal":["RSC advances"],"pagination":["39008-39016"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9057345"],"repository":["biostudies-literature"],"pubmed_title":["pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia."],"pmcid":["PMC9057345"],"pubmed_authors":["Khavandi A","Naimi-Jamal MR","Keshavarz H","Alamolhoda S"],"additional_accession":[]},"is_claimable":false,"name":"pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia.","description":"In clinical applications, chemotherapy and hyperthermia are commonly used together. To achieve this, we synthesized multifunctional magnetite mesoporous silica nanoparticles (MMSNs) coated with a chitosan hydrogel. pH-Responsive chitosan hydrogels (cross-linked glutaraldehyde) were used to cover mesoporous silica pores. The infrared spectroscopy (FT-IR) and electron microscopy images (SEM and TEM) confirm that a hydrogel layer and a silica shell were formed. By applying alternating magnetic fields (AMF) to nanogels, heat generation (43 °C) occurred within a short time. The drug release (tamoxifen) of nanogels was studied for 72 h at different pH and temperatures. Drug release at pH 7.4/<i>T</i> = 37 °C (simulating physiological condition) and pH 5/<i>T</i> = 43 °C (pH simulating endosomes/","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-26T15:23:35.134Z","creation":"2025-04-06T14:51:24.537Z"},"accession":"S-EPMC9057345","cross_references":{"pubmed":["35518395"],"doi":["10.1039/d0ra06916g"]}}