biostudies-literatureUnknown10(64)Keshavarz HIn clinical applications, chemotherapy and hyperthermia are commonly used together. To achieve this, we synthesized multifunctional magnetite mesoporous silica nanoparticles (MMSNs) coated with a chitosan hydrogel. pH-Responsive chitosan hydrogels (cross-linked glutaraldehyde) were used to cover mesoporous silica pores. The infrared spectroscopy (FT-IR) and electron microscopy images (SEM and TEM) confirm that a hydrogel layer and a silica shell were formed. By applying alternating magnetic fields (AMF) to nanogels, heat generation (43 °C) occurred within a short time. The drug release (tamoxifen) of nanogels was studied for 72 h at different pH and temperatures. Drug release at pH 7.4/<i>T</i> = 37 °C (simulating physiological condition) and pH 5/<i>T</i> = 43 °C (pH simulating endosomes/RSC advances39008-39016https://www.ebi.ac.uk/biostudies/studies/S-EPMC9057345biostudies-literaturepH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia.PMC9057345Khavandi ANaimi-Jamal MRKeshavarz HAlamolhoda SfalsepH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia.In clinical applications, chemotherapy and hyperthermia are commonly used together. To achieve this, we synthesized multifunctional magnetite mesoporous silica nanoparticles (MMSNs) coated with a chitosan hydrogel. pH-Responsive chitosan hydrogels (cross-linked glutaraldehyde) were used to cover mesoporous silica pores. The infrared spectroscopy (FT-IR) and electron microscopy images (SEM and TEM) confirm that a hydrogel layer and a silica shell were formed. By applying alternating magnetic fields (AMF) to nanogels, heat generation (43 °C) occurred within a short time. The drug release (tamoxifen) of nanogels was studied for 72 h at different pH and temperatures. Drug release at pH 7.4/<i>T</i> = 37 °C (simulating physiological condition) and pH 5/<i>T</i> = 43 °C (pH simulating endosomes/2020-01-01T00:00:00Z2020 Oct2025-04-26T15:23:35.134Z2025-04-06T14:51:24.537ZS-EPMC90573453551839510.1039/d0ra06916g