biostudies-literatureUnknown10(69)Yokota DAppropriately designed amphiphilic diblock vinyl ether (VE) copolymers consisting of an ionic liquid-type segment and a hydrophobic segment were demonstrated to undergo physical gelation in water at extremely low concentrations. The precursor diblock copolymers were synthesized by the living cationic polymerization of 2-chloroethyl VE with a hydrophobic VE through an appropriately designed initiating system such as optimized temperature and catalyst. A relatively high temperature such as 20 °C was important for controlled polymerization of octadecyl VE. Ionic liquid moieties with imidazolium salt structures were subsequently introduced into the side chains of the diblock copolymers <i>via</i> chemical modifications of the 2-chloroethyl groups. The physical gelation behavior of the obtained diblock copolymers was examined in water, with a particular focus on the influence of the hydrophobic VEs, the hydrophilicity of the counteranions and the substituents on the ionic liquid-type segments, and the length of each segment. Based on this systematic investigation, physical gelation at concentrations as low as 0.2 wt% was achieved with diblock copolymers with a suitable balance of these factors.RSC advances42378-42387https://www.ebi.ac.uk/biostudies/studies/S-EPMC9057971biostudies-literaturePrecise synthesis of amphiphilic diblock copolymers consisting of various ionic liquid-type segments and their influence on physical gelation behavior in water.PMC9057971Kanazawa AAoshima SYokota DfalsePrecise synthesis of amphiphilic diblock copolymers consisting of various ionic liquid-type segments and their influence on physical gelation behavior in water.Appropriately designed amphiphilic diblock vinyl ether (VE) copolymers consisting of an ionic liquid-type segment and a hydrophobic segment were demonstrated to undergo physical gelation in water at extremely low concentrations. The precursor diblock copolymers were synthesized by the living cationic polymerization of 2-chloroethyl VE with a hydrophobic VE through an appropriately designed initiating system such as optimized temperature and catalyst. A relatively high temperature such as 20 °C was important for controlled polymerization of octadecyl VE. Ionic liquid moieties with imidazolium salt structures were subsequently introduced into the side chains of the diblock copolymers <i>via</i> chemical modifications of the 2-chloroethyl groups. The physical gelation behavior of the obtained diblock copolymers was examined in water, with a particular focus on the influence of the hydrophobic VEs, the hydrophilicity of the counteranions and the substituents on the ionic liquid-type segments, and the length of each segment. Based on this systematic investigation, physical gelation at concentrations as low as 0.2 wt% was achieved with diblock copolymers with a suitable balance of these factors.2020-01-01T00:00:00Z2020 Nov2024-11-08T21:27:55.428Z2024-11-08T21:27:55.428ZS-EPMC90579713551678310.1039/d0ra09163d