biostudies-literatureChen HFundamental Research Funds for Central Universities of the Central South UniversityNatural Science Foundation of Hunan ProvinceNational Natural Science Foundation of China815450https://www.ebi.ac.uk/biostudies/studies/S-EPMC9058067biostudies-literatureUnknown9Globally, cervical cancer (CC) is the most common malignant tumor of the female reproductive system and its incidence is only second after breast cancer. Although screening and advanced treatment strategies have improved the rates of survival, some patients with CC still die due to metastasis and drug resistance. It is considered that cancer is driven by somatic mutations, such as single nucleotide, small insertions/deletions, copy number, and structural variations, as well as epigenetic changes. Previous studies have shown that cervical intraepithelial neoplasia is associated with copy number variants (CNVs) and/or mutations in cancer-related genes. Further, CC is also related to genetic mutations. The present study analyzed the data on somatic mutations of cervical squamous cell carcinomFrontiers in medicineBioinformatic Analyzes of the Association Between Upregulated Expression of <i>JUN</i> Gene <i>via APOBEC</i>-Induced <i>FLG</i> Gene Mutation and Prognosis of Cervical Cancer.PMC90580672021zzts0391Fang XXia XLiu JZhao LChen HWang XZhou HfalseBioinformatic Analyzes of the Association Between Upregulated Expression of <i>JUN</i> Gene <i>via APOBEC</i>-Induced <i>FLG</i> Gene Mutation and Prognosis of Cervical Cancer.Globally, cervical cancer (CC) is the most common malignant tumor of the female reproductive system and its incidence is only second after breast cancer. Although screening and advanced treatment strategies have improved the rates of survival, some patients with CC still die due to metastasis and drug resistance. It is considered that cancer is driven by somatic mutations, such as single nucleotide, small insertions/deletions, copy number, and structural variations, as well as epigenetic changes. Previous studies have shown that cervical intraepithelial neoplasia is associated with copy number variants (CNVs) and/or mutations in cancer-related genes. Further, CC is also related to genetic mutations. The present study analyzed the data on somatic mutations of cervical squamous cell carcinom2022-01-01T00:00:00Z20222026-04-08T18:21:53.497Z2025-04-05T19:57:27.459ZS-EPMC90580673551024810.3389/fmed.2022.815450