{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu MQ"],"funding":["National Basic Research Program of China"],"pagination":["43299-43311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9058255"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(71)"],"pubmed_abstract":["Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-<i>N</i>-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs."],"journal":["RSC advances"],"pubmed_title":["1-Phenyl-<i>N</i>-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors."],"pmcid":["PMC9058255"],"funding_grant_id":["2018YFC1200604"],"pubmed_authors":["Li H","Tang J","Zuo JP","Yu LF","Zhang Y","Lin Y","Hu MQ","Tang W","Tong XK","Yang F"],"additional_accession":[]},"is_claimable":false,"name":"1-Phenyl-<i>N</i>-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors.","description":"Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-<i>N</i>-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-06-01T03:01:14.17Z","creation":"2024-10-15T21:41:11.238Z"},"accession":"S-EPMC9058255","cross_references":{"pubmed":["35519683"],"doi":["10.1039/d0ra08442e"]}}