biostudies-literatureHu MQNational Basic Research Program of China43299-43311https://www.ebi.ac.uk/biostudies/studies/S-EPMC9058255biostudies-literatureUnknown10(71)Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-<i>N</i>-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.RSC advances1-Phenyl-<i>N</i>-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors.PMC90582552018YFC1200604Li HTang JZuo JPYu LFZhang YLin YHu MQTang WTong XKYang Ffalse1-Phenyl-<i>N</i>-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors.Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-<i>N</i>-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.2020-01-01T00:00:00Z2020 Nov2026-06-01T03:01:14.17Z2024-10-15T21:41:11.238ZS-EPMC90582553551968310.1039/d0ra08442e